5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole | 67968-90-5

分子结构分类

有机化合物 - 有机杂环化合物 - Dibenzazecins

中文名称

——

中文别名

——

英文名称

5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole

英文别名

5-Formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo<3,4;6,7>cyclohepta<1,2-c>pyrrol；5-Formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4;6,7]cyclohepta[1,2-c]pyrrol；3-(cyclopentylmethyl)-3-azapentacyclo[10.6.1.01,5.06,11.013,18]nonadeca-6,8,10,13(18),14,16-hexaene-16-carbaldehyde

5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole化学式

CAS

67968-90-5

化学式

C₂₅H₂₇NO

mdl

——

分子量

357.495

InChiKey

SVLYJICSAONXNV-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

计算性质

辛醇/水分配系数(LogP)：

4.8
重原子数：

27
可旋转键数：

3
环数：

6.0
sp3杂化的碳原子比例：

0.48
拓扑面积：

20.3
氢给体数：

0
氢受体数：

2

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole	737703-50-3	C₂₄H₂₇N	329.485

反应信息

作为反应物：

描述：

5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole 、氢气在 palladium-carbon 作用下，以溶剂黄146 、高氯酸为溶剂， 25.0 ℃ 、45.96 MPa 条件下，反应 16.0h，以to leave the product, 5-methyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole的产率得到5-methyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole

参考文献：

名称：

Methanodibenzocycloheptapyrroles

摘要：

甲烷二苯并环庚戊吡咯，例如2-环戊甲基-2,3,8,12b-四氢-1H-3a，8-甲烷二苯并[3,4:6,7]环庚七[1,2-c]吡咯，可用作镇静剂和镇痛剂。

公开号：

US04088772A1
作为产物：

描述：

2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole 、二氯甲醇在四氯化钛作用下，以二氯甲烷为溶剂，生成 5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole hydrochloride 、 5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole

参考文献：

名称：

Methanodibenzocycloheptapyrroles

摘要：

甲烷二苯环庚六吡咯烷吡咯烷，例如2-环戊基甲基-2,3,8,12b-四氢-1H-3a，8-甲烷二苯并[3,4:6,7]环庚七[1,2-c]吡咯烷，可用作镇静剂和止痛药。

公开号：

US04088772A1

点击查看最新优质反应信息

文献信息

US4088772A

申请人：——

公开号：US4088772A

公开（公告）日：1978-05-09

同类化合物

5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole hydrochloride dibenzo[i,k]-benzo[4,5]imidazo[1,2-f]phenanthridine 2-{4-[9-(5,8,9,14-tetrahydrodibenzo[d,g]azecin-7(6H)-yl)nonyl]piperazin-1-yl}ethanol (2R,3aR,12bS)-11-fluoro-2-[(methylamino)methyl]-3,3a,8,12b-tetrahydrodibenzo[3,4:6,7]cyclohepta[1,2-b]pyrrole-1(2H)-carbaldehyde [(2R,3aR,12bS)-11-fluoro-1-(methoxyacetyl)-1,2,3,3a,8,12b-hexahydrodibenzo-[3,4:6,7]cyclohepta[1,2-b]pyrrol-2-yl]-N,N-dimethylmethanamine 2-[(2R,3aR,12bS)-2-[(dimethylamino)methyl]-11-fluoro-3,3a,8,12b-tetrahydrodibenzo[3,4:6,7]cyclohepta[1,2-b]pyrrol-1(2H)-1-yl]ethanol [(2R,3aR,12bS)-11-fluoro-1-(2-methoxyethyl)-1,2,3,3a,8,12b-hexahydrodibenzo[3,4:6,7]cyclohepta[1,2-b]pyrrol-2-yl]-N,N-dimethylmethanamine [(2R,3aR,12bS)-11-fluoro-1-methyl-1,2,3,3a,8,12b-hexahydrodibenzo[3,4:6,7]cyclohepta[1,2-b]pyrrol-2-yl]-N,N-dimethylmethanamine methyl (2R,3aR,12bS)-2-(aminomethyl)-11-fluoro-3,3a,8,12b-tetrahydrodibenzo[3,4:6,7]cyclohepta[1,2-b]pyrrole-1(2H)-carboxylate 6-allyl-3,4-dimethoxy-10-hydroxy-5,6,7,8,13,14-hexahydrodibenz[c,g]azecine 6,7,15-trimethyl-7-nitro-5,6,6a,7,8,13,14,14a-octahydro-5,13-cyclo-8,14-epiazano-benzo[5,6]cycloocta[1,2-c]isoquinoline 6-Benzyl-3,4-dimethoxy-10-hydroxy-5,6,7,8,13,14-hexahydrodibenz[c,g]azecine 3,4-Dimethoxy-11-hydroxy-6-methyl-5,6,7,8.13,14-hexahydrodibenz[c,g]azecine 6-benzyl-3,4-dimethoxy-11-hydroxy-5,6,7,8,13,14-hexahydrodibenz[c,g]azecine 2,3-dimethoxy-7-methyl-5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizinium iodide 5,6-Dimethoxy-11-methyl-11-aza-tricyclo[12.4.0.0^3,8]octadeca-1(14),3(8),4,6,15,17-hexaene (3S,3aR,12bS)-8-Dicyanomethylene-2,3-diphenyl-3,3a,8,12b-tetrahydro-2H-dibenzo[3,4;6,7]cyclohepta[1,2-c]pyrrole-1,1-dicarboxylic acid dimethyl ester (3S,3aR,12bS)-8-Dicyanomethylene-2-phenyl-3,3a,8,12b-tetrahydro-2H-dibenzo[3,4;6,7]cyclohepta[1,2-c]pyrrole-1,1,3-tricarboxylic acid trimethyl ester markiertes 2-Nitro-4,13-dimethyl-4,13-diazadibenzo<6.7,11,12>tetracyclo<7.3.1.0^3,8.0⁵,10>tridecadien-(6,11) 3,4-dimethoxy-6-methyl-5,6,7,8,13,14-hexahydro-dibenzo[c,g]azecin-10-ol (2R,3aR,12bS)-11-fluoro-2-(hydroxymethyl)-3,3a,8,12b-tetrahydrodibenzo[3,4:6,7]cyclohepta[1,2-b]pyrrole-1(2H)-carbaldehyde 1H-3a,8-Methanodibenzo(3,4:6,7)cyclohepta(1,2-c)pyrrole, 2,3,8,12b-tetrahydro-2-(cyclohexylmethyl)-8-methyl-, hydrochloride, (3a-alpha,8-alpha,12b-beta)- 1H-3a,8-Methanodibenzo(3,4:6,7)cyclohepta(1,2-c)pyrrole, 2,3,8,12b-tetrahydro-2-(cyclopentylmethyl)-1-methyl-, hydrochloride, (1-alpha,3a-alpha,8-alpha,12b-beta)- 3,12-dimethyl-3-azapentacyclo[10.6.1.01,5.06,11.013,18]nonadeca-6,8,10,13,15,17-hexaene;hydron;chloride 14-hydroxy-3,4-dimethoxy-5,6,7,8,14,15-hexahydrobenzo<1,3>dioxolo<4,5-k><3>benzazecine-6-carbonitrile 7-methyl-5,6,7,8,9,15-hexahydrobenzo[d][1,3]benzodioxolo[5,6-g]azecine 6-Acetyl-3,4-dimethoxy-5,8,14,15-tetrahydro-6H-benzo[c][1,3]dioxolo[4',5':4,5]benzo[1,2-g]azecin-7-one 6-benzyl-3,4-dimethoxy-10,11-methylenedioxy-5,6,7,8,13,14-hexahydrodibenz[c,g]azecine 4MP-Dhx 6-methyl-5,6,7,8,9,14-hexahydrodibenzo[c,f]azecin-11-ol 10-methoxy-6-methyl-5,6,7,8,13,14-hexahydrodibenzo[c,g]azecine 3,3a(2)-[1,3-Propanediylbis(oxy)]bis[5,8,9,13b-tetrahydro-7-methyl-6H-dibenzo[a,h]quinolizinium] 7-methyl-6,7,8,9-tetrahydrodibenz[d,g]azecin-14(5H)-one N-benzyl-N-nordihydroallocryptopine 2-Methyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo<3,4;6,7>cyclohepta<1,2-c>pyrrol-1-on dihydroallocryptopine 3-methoxy-7-methyl-6,7,8,9-tetrahydrodibenz[d,g]azecin-14(5H)-one (6aR,12bS)-(+)-6-((R)-α-methoxyphenylacetyl)-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine (6aS,12bR)-(-)-6-((R)-α-methoxyphenylacetyl)-10,11-dimethoxy-5,6,6a,7,8,12b-hexahydrobenzo phenanthridine 2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole 5-formyl-2-cyclopentylmethyl-2,3,8,12b-tetrahydro-1H-3a,8-methanodibenzo[3,4:6,7]cyclohepta[1,2-c]pyrrole (1S,2S,9R,11R,12S,13S,20R)-10,21-dimethyl-12-nitro-10,21-diazahexacyclo[11.7.1.02,11.03,8.09,20.014,19]henicosa-3,5,7,14,16,18-hexaene (1S,2S,9S,11R,12S,13S,20R)-10,21-dimethyl-12-nitro-10,21-diazahexacyclo[11.7.1.02,11.03,8.09,20.014,19]henicosa-3,5,7,14,16,18-hexaene 6-benzyl-10,11-dimethoxy-2-phenyl-6a,7,8,12b-tetrahydro-5H-benzo[a]phenanthridine 6-Propyl-5,6,6a,7,8,12b-hexahydro-benzo[a]phenanthridine-10,11-diol (2S)-7,8-dimethoxy-11-methyl-17,19-dioxa-11-azoniatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-ol (2R)-7,8-dimethoxy-11-methyl-17,19-dioxa-11-azoniatetracyclo[12.7.0.04,9.016,20]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-ol 7-Methyl-5,6,7,8,9,14-hexahydrodibenzo[d,g]azecine (3R)-15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-ol (3S)-15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-ol