Dibenzyl 2-(dimethylamino)ethyl phosphate | 130256-78-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Dibenzyl 2-(dimethylamino)ethyl phosphate
• CAS: 130256-78-9
• 化学式: C₁₈H₂₄NO₄P
• 分子量: 349.367
• InChiKey: WGRWLPVNBICVKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Dibenzyl 2-(dimethylamino)ethyl phosphate 在 氢气 、 palladium(II) hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以87%的产率得到2-二甲基氨基乙基磷酸酯
  参考文献：
  名称：

  Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3′ cleavage reaction

  摘要：

  The 3' end formation of mammalian pre-mRNA contributes to gene expression regulation by setting the downstream boundary of the 3' untranslated region, which in many genes carries regulatory sequences. A large number of protein cleavage factors participate in this pre-mRNA processing step, but chemical tools to manipulate this process are lacking. Guided by a hypothesis that a PPM1 family phosphatase negatively regulates the 3' cleavage reaction, we have found a variety of new small molecule activators of the in vitro reconstituted pre-mRNA 3' cleavage reaction. New activators include a cyclic peptide PPM1D inhibitor, a dipeptide with modifications common to histone tails, abscisic acid and an improved L-arginine beta-naphthylamide analog. The minimal concentration required for in vitro cleavage has been improved from 200 mu M to the 200 nM-100 mu M range. These compounds provide unexpected leads in the search for small molecule tools able to affect pre-mRNA 3' end formation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.12.006
• 作为产物：
  描述：

  、 苯甲醇 在 sodium hydride 作用下， 以 乙醚 、 mineral oil 为溶剂， 反应 1.0h， 以58%的产率得到Dibenzyl 2-(dimethylamino)ethyl phosphate
  参考文献：
  名称：

  Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3′ cleavage reaction

  摘要：

  The 3' end formation of mammalian pre-mRNA contributes to gene expression regulation by setting the downstream boundary of the 3' untranslated region, which in many genes carries regulatory sequences. A large number of protein cleavage factors participate in this pre-mRNA processing step, but chemical tools to manipulate this process are lacking. Guided by a hypothesis that a PPM1 family phosphatase negatively regulates the 3' cleavage reaction, we have found a variety of new small molecule activators of the in vitro reconstituted pre-mRNA 3' cleavage reaction. New activators include a cyclic peptide PPM1D inhibitor, a dipeptide with modifications common to histone tails, abscisic acid and an improved L-arginine beta-naphthylamide analog. The minimal concentration required for in vitro cleavage has been improved from 200 mu M to the 200 nM-100 mu M range. These compounds provide unexpected leads in the search for small molecule tools able to affect pre-mRNA 3' end formation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.12.006

文献信息

• MODRO, T. A.;MOORHOFF, C. M., J. PHYS. ORG. CHEM., 2,(1989) N, C. 263-270
  作者：MODRO, T. A.、MOORHOFF, C. M.

  DOI：——

  日期：——
• Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3′ cleavage reaction
  作者：Min Ting Liu、Nagaraja N. Nagre、Kevin Ryan

  DOI：10.1016/j.bmc.2013.12.006

  日期：2014.1

  The 3' end formation of mammalian pre-mRNA contributes to gene expression regulation by setting the downstream boundary of the 3' untranslated region, which in many genes carries regulatory sequences. A large number of protein cleavage factors participate in this pre-mRNA processing step, but chemical tools to manipulate this process are lacking. Guided by a hypothesis that a PPM1 family phosphatase negatively regulates the 3' cleavage reaction, we have found a variety of new small molecule activators of the in vitro reconstituted pre-mRNA 3' cleavage reaction. New activators include a cyclic peptide PPM1D inhibitor, a dipeptide with modifications common to histone tails, abscisic acid and an improved L-arginine beta-naphthylamide analog. The minimal concentration required for in vitro cleavage has been improved from 200 mu M to the 200 nM-100 mu M range. These compounds provide unexpected leads in the search for small molecule tools able to affect pre-mRNA 3' end formation. (C) 2013 Elsevier Ltd. All rights reserved.