Dipropan-2-yl 2,2,3,3-tetrafluoropropyl phosphate | 145284-62-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Dipropan-2-yl 2,2,3,3-tetrafluoropropyl phosphate
• CAS: 145284-62-4
• 化学式: C₉H₁₇F₄O₄P
• 分子量: 296.199
• InChiKey: DSKULIZKIABBMA-UHFFFAOYSA-N

物化性质

• 沸点：
  259.7±40.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  亚磷酸二异丙酯 、 四氟丙醇 在 三乙胺 作用下， 以 四氯化碳 为溶剂， 以65%的产率得到Dipropan-2-yl 2,2,3,3-tetrafluoropropyl phosphate
  参考文献：
  名称：

  Polyfluoroalkoxy phosphonic and phosphinic acid derivatives: II. Reversible esterase inhibitors

  摘要：

  Polyfluoroalkyl esters of phosphoric, alkylphosphonic and 1-hydroxypolyfluoroalkylphosphonic acids exhibited significant antiesterase activity against various esterases of animal and microbial origin. Moreover, with some compounds reversible inhibition of enzymes was observed due to the specific influence of hydrophobic fragments of the target products.

  DOI：

  10.1134/s1070363210030102

文献信息

• Polyfluoroalkoxy phosphonic and phosphinic acid derivatives: II. Reversible esterase inhibitors
  作者：V. V. Krutikova、V. I. Krutikov、A. V. Erkin

  DOI：10.1134/s1070363210030102

  日期：2010.3

  Polyfluoroalkyl esters of phosphoric, alkylphosphonic and 1-hydroxypolyfluoroalkylphosphonic acids exhibited significant antiesterase activity against various esterases of animal and microbial origin. Moreover, with some compounds reversible inhibition of enzymes was observed due to the specific influence of hydrophobic fragments of the target products.