1'-ethyl-4-hydroxy-2,8,8-trimethyl-5'-nitro-8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-2',6(7H)-dione | 1246222-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃嘧啶类
• 英文名称: 1'-ethyl-4-hydroxy-2,8,8-trimethyl-5'-nitro-8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-2',6(7H)-dione
• 英文别名: 1'-ethyl-2,8,8-trimethyl-5'-nitrospiro[7,9-dihydro-3H-chromeno[2,3-d]pyrimidine-5,3'-indole]-2',4,6-trione
• CAS: 1246222-50-3
• 化学式: C₂₃H₂₂N₄O₆
• 分子量: 450.451
• InChiKey: ARQSJVLZAYUPOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  33
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  134
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-nitro-N-ethylisatin 、 5,5-二甲基-1,3-环己二酮 、 2-甲基-4,6-二羟基嘧啶 在 对甲苯磺酸 作用下， 以 水 为溶剂， 反应 15.0h， 以82%的产率得到1'-ethyl-4-hydroxy-2,8,8-trimethyl-5'-nitro-8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-2',6(7H)-dione
  参考文献：
  名称：

  One-pot and three-component synthesis of spiro[chromeno[2,3-d] pyrimidine-5,3′-indoline]-diones and spiro[chromeno[2,3-c] pyrazole-4,3′-indoline]-diones

  摘要：

  Abstract magnified image A novel, clean, one‐pot and three‐component synthesis of new spiro[chromeno[2,3‐d]pyrimidine‐5,3′‐indoline]‐2′,6(7H)‐diones and spiro[chromeno[2,3‐c]pyrazole‐4,3′‐indoline]‐2′,5(6H)‐diones via cyclo‐condensation reaction of isatins, 1,3‐cyclohexadiones, and 2‐methylpyrimidine‐4,6‐diol or 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ol, in aqueous media is reported. J. Heterocyclic Chem., (2010).

  DOI：

  10.1002/jhet.399

文献信息

• One-pot and three-component synthesis of spiro[chromeno[2,3-d] pyrimidine-5,3′-indoline]-diones and spiro[chromeno[2,3-c] pyrazole-4,3′-indoline]-diones
  作者：Ramin Ghahremanzadeh、Fatemeh Fereshtehnejad、Zahra Yasaei、Tayebeh Amanpour、Ayoob Bazgir

  DOI：10.1002/jhet.399

  日期：——

  Abstract magnified image A novel, clean, one‐pot and three‐component synthesis of new spiro[chromeno[2,3‐d]pyrimidine‐5,3′‐indoline]‐2′,6(7H)‐diones and spiro[chromeno[2,3‐c]pyrazole‐4,3′‐indoline]‐2′,5(6H)‐diones via cyclo‐condensation reaction of isatins, 1,3‐cyclohexadiones, and 2‐methylpyrimidine‐4,6‐diol or 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ol, in aqueous media is reported. J. Heterocyclic Chem., (2010).