(1E)-1-(6-methylidenecyclohexa-2,4-dien-1-ylidene)ethanol | 122382-54-1

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物 - 醌二甲烷类
• 英文名称: (1E)-1-(6-methylidenecyclohexa-2,4-dien-1-ylidene)ethanol
• CAS: 122382-54-1
• 化学式: C₉H₁₀O
• 分子量: 134.178
• InChiKey: JOOXKAJAHXLBNC-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1E)-1-(6-methylidenecyclohexa-2,4-dien-1-ylidene)ethanol 在 sodium hydroxide 作用下， 以 various solvent(s) 为溶剂， 生成 1-甲基苯基乙酮
  参考文献：
  名称：

  Scavenging of photoenols by acids and bases

  摘要：

  Photoenols generated by irradiation of ortho-methylacetophenone, ortho-methylbenzophenone and ortho -benzylbenzophenone are readily quenched by acids and bases. The rate constants for these reactions have been determined employing laser flash photolysis techniques.

  DOI：

  10.1016/s0040-4039(00)61085-7

文献信息

• [EN] NEUROPROTECTIVE POLYPHENOL ANALOGS<br/>[FR] ANALOGUES DU POLYPHÉNOL NEUROPROTECTEURS
  申请人：SCHUBERT DAVID R

  公开号：WO2013025498A1

  公开（公告）日：2013-02-21

  The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzherimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.

  本发明提供了神经保护多酚化合物，可以是嘌呤、黄芩素或绿原酸的合成类似物，这些化合物具有保持神经保护、抗炎、促进谷胱甘肽以及抗氧化性能。这些神经保护多酚化合物可用于促进、增强和/或增加神经元的保护、生长和/或再生。多酚化合物还可用于增加和/或维持细胞内谷胱甘肽（GSH）水平。多酚化合物还可用于治疗、预防、缓解和/或延缓神经退行性疾病，包括糖尿病、帕金森病、亨廷顿病、阿尔茨海默病、非阿尔茨海默病性痴呆、多发性硬化症、创伤性脑损伤、脊髓损伤或肌萎缩侧索硬化症（ALS）。
• Scavenging of photoenols by acids and bases
  作者：J.C. Scaiano、Véronique Wintgens、J.C. Netto-Ferreira

  DOI：10.1016/s0040-4039(00)61085-7

  日期：1992.9

  Photoenols generated by irradiation of ortho-methylacetophenone, ortho-methylbenzophenone and ortho -benzylbenzophenone are readily quenched by acids and bases. The rate constants for these reactions have been determined employing laser flash photolysis techniques.