3,6-diethyl-1,2,4,5-tetrathiane | 934273-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四硫烷
• 英文名称: 3,6-diethyl-1,2,4,5-tetrathiane
• CAS: 934273-77-5；54717-12-3
• 化学式: C₆H₁₂S₄
• 分子量: 212.425
• InChiKey: WASBDGZBDGMWMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  dithiopropionic acid 生成 3,6-diethyl-1,2,4,5-tetrathiane
  参考文献：
  名称：

  BONNANS-PLAISANCE C.; MAHJOUB A.; LEVESQUE G., TETRAHEDRON LETT., 1980, 21, NO 20, 1941-1942

  摘要：

  DOI：

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Characterization of Key Odorants in Scallion Pancake and Investigation on Their Changes during Storage
  作者：Binshan Liu、Shiqi Xu、Zhizhong Dong、Yuping Liu、Xiaoming Wei、Danqing Shao

  DOI：10.3390/molecules26247647

  日期：——

  To characterize key odorants in scallion pancake (SP), volatiles were extracted by solvent extraction-solvent assisted flavor evaporation. A total of 51 odor-active compounds were identified by gas chromatography-olfactometry (GC-O) and chromatography–mass spectrometry (GC-MS). (Z/E)-3,6-Diethyl-1,2,4,5-tetrathiane was detected for the first time in scallion food. Application of aroma extract dilution analysis to extracts showed maltol, methyl propyl disulfide, dipropyl disulfide and 2-pentylfuran had the highest flavor dilution (FD) factor of 4096. Twenty-three odorants with FD factors ≥ 8 were quantitated, and their odor active values (OAVs) were calculated. Ten compounds with OAVs ≥ 1 were determined as the key odorants; a recombinate model prepared from the key odorants, including (E,E)-2,4-decadienal, dimethyl trisulfide, methyl propyl disulfide, hexanal, dipropyl trisulfide, maltol, acetoin, 2-methylnaphthalene, 2-pentylfuran and 2(5H)-furanone, successfully simulated the overall aroma profile of SP. The changes in odorants during storage were investigated further. With increasing concentrations and OAVs during storage, hexanal became an off-flavor compound.

  为了表征葱油饼的关键气味成分，通过溶剂萃取-溶剂辅助风味蒸发提取挥发性化合物。通过气相色谱-嗅觉法（GC-O）和色谱-质谱联用（GC-MS）鉴定了51种气味活性化合物。其中（Z/E）-3,6-二乙基-1,2,4,5-四硫杂环已首次在葱类食品中被检测到。应用香气萃取稀释分析对提取物进行分析，发现麦芽酚、甲基丙基二硫化物、双丙基二硫化物和2-戊基呋喃的味道稀释（FD）因子最高，为4096。测定了23种FD因子≥8的气味物质，并计算了它们的气味活性值（OAVs）。确定了10种OAVs≥1的化合物为关键气味成分；从关键气味成分中制备的复合模型，包括（E,E）-2,4-十二烯醛、三甲基三硫、甲基丙基二硫化物、己醛、双丙基三硫化物、麦芽酚、乙酰乙酸乙酯、2-甲基萘、2-戊基呋喃和2（5H）-呋喃酮，成功模拟了葱油饼的整体香气特征。进一步研究了储存过程中气味物质的变化。随着储存过程中浓度和OAVs的增加，己醛成为了一种异味化合物。
• Compounds useful as modulators of TRPM8
  申请人：Senomyx, Inc.

  公开号：US10392371B2

  公开（公告）日：2019-08-27

  Provided herein are compounds which are useful as cooling sensation compounds.

  本文提供的化合物可用作冷感化合物。
• High intensity sweeteners
  申请人：Firmenich Incorporated

  公开号：US11357246B2

  公开（公告）日：2022-06-14

  Disclosed herein are compounds having structural Formula (I), or salts thereof. These compounds are useful as sweet tasting agents and/or sweetness enhancers. Also disclosed are compositions comprising the present compounds and methods of increasing the sweet taste of ingestible compositions. Furthermore, methods for preparing the compounds are also disclosed.

  本文公开了具有结构式（I）的化合物或其盐类。这些化合物可用作甜味剂和/或甜味增强剂。还公开了包含本化合物的组合物以及增加可食用组合物甜味的方法。此外，还公开了制备这些化合物的方法。