pyridin-2-yl(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone | 190012-41-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: pyridin-2-yl(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
• 英文别名: 1,4-Dioxa-8-azaspiro[4.5]decan-8-yl(pyridin-2-yl)methanone
• CAS: 190012-41-0
• 化学式: C₁₃H₁₆N₂O₃
• mdl: MFCD13386448
• 分子量: 248.282
• InChiKey: WARNHBQZVZSUPG-UHFFFAOYSA-N

物化性质

• 沸点：
  433.4±45.0 °C(Predicted)
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-吡啶甲酸乙酯 、 4-哌啶酮缩乙二醇 在 lanthanum(lll) triflate 作用下， 反应 1.0h， 以99%的产率得到pyridin-2-yl(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone
  参考文献：
  名称：

  Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters

  摘要：

  Lanthanum trifluoromethanesulfonate is an effective single-component catalyst for synthesizing a variety of amides directly from esters and amines under mild conditions. Highly selective amidation of esters and amines, as well as catalyst-controlled amidation of esters, demonstrated the effectiveness of the catalyst system.

  DOI：

  10.1021/ol500593v

文献信息

• Lanthanum(III) Triflate Catalyzed Direct Amidation of Esters
  作者：Hiroyuki Morimoto、Risa Fujiwara、Yuhei Shimizu、Kazuhiro Morisaki、Takashi Ohshima

  DOI：10.1021/ol500593v

  日期：2014.4.4

  Lanthanum trifluoromethanesulfonate is an effective single-component catalyst for synthesizing a variety of amides directly from esters and amines under mild conditions. Highly selective amidation of esters and amines, as well as catalyst-controlled amidation of esters, demonstrated the effectiveness of the catalyst system.