4,7-Diazaspiro[2.6]nonane | 235106-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 4,7-Diazaspiro[2.6]nonane
• CAS: 235106-30-6
• 化学式: C₇H₁₄N₂
• 分子量: 126.2
• InChiKey: IGNVXSGDOWAEBU-UHFFFAOYSA-N

物化性质

• 沸点：
  211.2±8.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE<br/>[FR] MONOBACTAMES ET PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION DE CES DERNIERS
  申请人：HARVARD COLLEGE

  公开号：WO2015103583A1

  公开（公告）日：2015-07-09

  Described herein are monobactam antibiotics of Formula (I), (Ι'), (II), and (II'), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.

  本文描述了单环内酰胺抗生素的化学式(I)、(Ι')、(II)和(II')，以及制备这些化合物的方法和中间体。还提供了使用单环内酰胺治疗传染病的药物组合物和方法。
• HOMOPIPERAZINE-BASED CATALYSTS FOR NEUTRALIZATION OF ORGANOPHOSPHORUS-BASED COMPOUNDS
  申请人：Lawrence Livermore National Security, LLC

  公开号：US20170253568A1

  公开（公告）日：2017-09-07

  Novel compositions of matter based on homopiperazine precursor materials and forming a homopiperazine-based ligand are disclosed, along with suitable techniques and materials for the synthesis and utilization thereof. In particular various synthetic schemes and techniques for applying the disclosed compositions of matter as a decontaminating agent. The decontaminating agents include homopiperazine-based ligand-metal complexes that are particularly effective at neutralizing toxicity of nerve agents, pesticides, and other toxic organophosphorus-based compounds. In preferred approaches, the homopiperazine-based ligand-metal complexes act as catalysts to facilitate substitution of a leaving group of the organophosphorus-based compound with a functional group that does not permit the organophosphorus-based compound to inactivate acetylcholinesterase upon introduction of the organophosphorus-based compound to a living organism such as insects and mammals. Advantageously, the catalytic homopiperazine-based ligand-metal complexes are formed using inexpensive, readily-available precursor materials, and may be utilized to neutralize toxins without relying on damaging caustic reactants or environmentally unfriendly organic solvents.

  基于同环异丙二胺前体材料的新型物质组合物以及形成基于同环异丙二胺的配体的方法被披露，还有适用的合成和利用技术和材料。特别是各种合成方案和技术，用于将披露的物质组合物作为除污剂。这些除污剂包括基于同环异丙二胺配体-金属配合物，特别有效地中和神经毒剂、杀虫剂和其他有机磷基化合物的毒性。在首选方法中，基于同环异丙二胺的配体-金属配合物作为催化剂，促进有机磷基化合物的脱离基团被一个功能基团替代，该功能基团不允许有机磷基化合物在引入有机磷基化合物到昆虫和哺乳动物等生物体时使乙酰胆碱酯酶失活。优点是，这种催化同环异丙二胺基配体-金属配合物是使用廉价、易得的前体材料形成的，并且可以用于中和毒素，而不依赖于有害的腐蚀性反应物或环境不友好的有机溶剂。
• MONOBACTAMS AND METHODS OF THEIR SYNTHESIS AND USE
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20160326157A1

  公开（公告）日：2016-11-10

  Described herein are monobactam antibiotics of Formula (I), (I′), (II), and (II′), along with methods and intermediates for preparing these compounds. Pharmaceutical compositions and methods of treating infectious diseases using the monobactams are also provided.