7,9-diethyl-6,7,9-trimethyl-8-(1-phenyl-ethoxy)-1,4-dioxa-8-aza-spiro[4.5]decane | 437744-12-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 7,9-diethyl-6,7,9-trimethyl-8-(1-phenyl-ethoxy)-1,4-dioxa-8-aza-spiro[4.5]decane
• 英文别名: 7,9-Diethyl-6,7,9-trimethyl-8-(1-phenylethoxy)-1,4-dioxa-8-azaspiro[4.5]decane
• CAS: 437744-12-2
• 化学式: C₂₂H₃₅NO₃
• 分子量: 361.525
• InChiKey: IRKNFCKUNPYFFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  30.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• N-alkoxy-4,4-dioxy-polyalkyl-piperidine compounds, their corresponding N-oxides and controlled radical polymerization therewith
  申请人：Nesvadba Peter

  公开号：US20060149011A1

  公开（公告）日：2006-07-06

  The present invention relates to selected 1-alkoxy-2,2,6,6 tetramethyl piperidine, 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 dimethyl piperidine derivatives which are substituted in the 4 position by two oxygen atoms forming an open chain or cyclic ketal structure, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) said piperidine derivatives. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers, and the use of 1-alkoxy-2,2,6,6 tetramethyl piperidine, 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 dimethyl piperidine derivatives which are substituted in the 4 position by two oxygen atoms forming an open chain or cyclic ketal structure for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator, as well as a process for polymerization are also subjects of the present invention.

  本发明涉及选择的1-烷氧基-2,2,6,6四甲基哌啶，1-烷氧基-2,2二乙基-6,6二甲基哌啶和1-烷氧基-2,6二乙基-2,3,6二甲基哌啶衍生物，其在4位被两个氧原子取代，形成开链或环状璃缩酮结构，包括a）至少一种乙烯基不饱和单体和b）所述哌啶衍生物的可聚合组合物。本发明的其他方面包括聚合乙烯基不饱和单体的方法，以及使用1-烷氧基-2,2,6,6四甲基哌啶、1-烷氧基-2,2二乙基-6,6二甲基哌啶和1-烷氧基-2,6二乙基-2,3,6二甲基哌啶衍生物，其在4位被两个氧原子取代，形成开链或环状璃缩酮结构，用于受控聚合。中间体N-氧基衍生物，N-氧基衍生物与乙烯基不饱和单体和自由基引发剂的组合物，以及聚合方法也是本发明的对象。
• IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20140206675A1

  公开（公告）日：2014-07-24

  In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 9 , ring A, ring B, m, n, p, -L 1 -, L 2 -, and L 3 - is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (Aβ) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination nation with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers disease, are also disclosed.

  在其不同实施例中，本发明提供某些亚氨基噻二嗪二氧化物化合物，包括化合物公式（I）：（I），并包括其立体异构体和药学上可接受的盐，其中R1、R2、R3、R4、R5、R9、环A、环B、m、n、p、-L1-、L2-和L3-各自独立选择并按照定义选定。本发明的新型亚氨基噻二嗪二氧化物化合物出人意料地发现具有预期的性质，这些性质使它们有望成为BACE抑制剂和/或用于治疗和预防与β-淀粉样蛋白（Aβ）产生相关的各种病理的优势。本发明还揭示了包括一个或多个此类化合物（独立和与一个或多个其他活性剂联合使用）的药物组合物，并揭示了用于制备和治疗与淀粉样β（Aβ）蛋白相关的病理，包括阿尔茨海默病的方法。
• N-alkoxy-4,4-dioxy-polyalkyl-piperidine compounds, their corresponding n-oxides and controlled radical polymerization therewith
  申请人：——

  公开号：US20040082742A1

  公开（公告）日：2004-04-29

  The present invention relates to selected 1-alkoxy-2,2,6,6 tetramethyl piperidine, 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 dimethyl piperidine derivatives which are substituted in the 4 position by two oxygen atoms forming an open chain or cyclic ketal structure, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) said piperidine derivatives. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers, and the use of 1-alkoxy-2,2,6,6 tetramethyl piperidine, 1-alkoxy-2,2 diethyl-6,6 dimethyl piperidine and 1-alkoxy-2,6 diethyl-2,3,6 dimethyl piperidine derivatives which are substituted in the 4 position by two oxygen atoms forming an open chain or cyclic ketal structure for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator, as well as a porcess for polymerization are also subjects of the present invention.

  本发明涉及精选的1-烷氧基-2,2,6,6四甲基哌啶、1-烷氧基-2,2二乙基-6,6二甲基哌啶和1-烷氧基-2,6二乙基-2,3,6二甲基哌啶衍生物，这些衍生物在4位被两个氧原子取代，形成开链或环酮结构，可聚合组合物包括a)至少一种乙烯基不饱和单体和b)上述哌啶衍生物。本发明的其他方面是一种乙烯基不饱和单体的聚合工艺，以及 1-烷氧基-2,2,6,6 四甲基哌啶、1-烷氧基-2,2 二乙基-6,6 二甲基哌啶和 1-烷氧基-2,6 二乙基-2,3,6 二甲基哌啶衍生物的使用，这些衍生物在 4 位被两个氧原子取代，形成开链或环酮结构，用于受控聚合。本发明还涉及中间体 N-氧代衍生物、N-氧代衍生物与乙烯基不饱和单体和自由基引发剂的组合物以及聚合工艺。
• N-ALKOXY-4,4-DIOXY-POLYALKYL-PIPERIDINE COMPOUNDS, THEIR CORRESPONDING N-OXIDES AND CONTROLLED RADICAL POLYMERIZATION THEREWITH
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1343827A1

  公开（公告）日：2003-09-17
• US7288613B2
  申请人：——

  公开号：US7288613B2

  公开（公告）日：2007-10-30