(6S,11R)-3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 6,7-苯并吗啡烷
• 英文名称: (6S,11R)-3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one
• 英文别名: Ethylketazocine；3-Cyclopropylmethyl-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2H-2,6-methano-benzo[d]azocin-1-one；(1S,13R)-10-(cyclopropylmethyl)-1-ethyl-4-hydroxy-13-methyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-8-one
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.413
• InChiKey: SEJUQQOPVAUETF-BKBNBNODSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] QUATERNARY OPIOID CARBOXAMIDES<br/>[FR] CARBOXAMIDES OPIOÏDES QUATERNAIRES
  申请人：RENSSELAER POLYTECH INST

  公开号：WO2009023567A1

  公开（公告）日：2009-02-19

  Compounds of formulas (A) and (B) are disclosed. The compounds of this invention are useful for ameliorating the side effects of therapeutic opiates.

  本发明揭示了化合物(A)和(B)的配方。本发明的化合物对于缓解治疗阿片类药物的副作用很有用。
• QUATERNARY OPIOID CARBOXAMIDES
  申请人：Wentland Mark P.

  公开号：US20120302594A1

  公开（公告）日：2012-11-29

  Compounds of formulas: are disclosed. The compounds are useful for ameliorating the side effects of therapeutic opiates.

  公式为的化合物被披露。这些化合物可用于改善治疗阿片类药物的副作用。
• 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS
  申请人：Fairfax David J.

  公开号：US20130045165A1

  公开（公告）日：2013-02-21

  4-Fluoro-4-phenylpiperidin- 1 -yl μ antagonists of general structure as well as pharmaceutical compositions comprising compounds of formula I, are disclosed. These compounds and compositions are useful as treatments of conditions or diseases associated with binding opioid receptors including pain, obesity, hyperalgesia, inflammation, osteoarthritis, drug addiction, and cancer. These compounds and compositions are also useful as treatments for tardive dyskinesia.

  本发明涉及一种通用结构的4-氟-4-苯基哌啶-1-基μ拮抗剂，以及包含式I化合物的制药组合物。这些化合物和组合物可用于治疗与结合阿片受体有关的疾病或症状，包括疼痛、肥胖症、高痛敏性、炎症、骨关节炎、药物成瘾和癌症。这些化合物和组合物还可用于治疗迟发性运动障碍。
• 8-carboxamido-substituted-2, 6-methano-3-benzazocines and 3-carboxamido-substituted morphanes as opioid receptor binding agents
  申请人：RENSSELAER POLYTECHNIC INSTITUTE

  公开号：EP2266959A1

  公开（公告）日：2010-12-29

  8-Substituted-2,6-methano-3-benzazocines of general structure are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. One embodiment is the subgenus of biphenylethyl compounds:

  一般结构的 8-取代-2,6-甲桥-3-苯并氮杂环丁烷 可用作镇痛剂、止泻剂、抗惊厥剂、抗惊厥剂和抗成瘾药物。其中一种是联苯乙化合物亚属：
• 8-CARBOXAMIDO-SUBSTITUTED-2 , 6-METHANO-3-BENZAZOCINES AND 3 - CARBOXAMIDO- SUBSTITUTED MORPHANES AS OPIOID RECEPTOR BINDING AGENTS
  申请人：RENSSELAER POLYTECHNIC INSTITUTE

  公开号：EP1924559B1

  公开（公告）日：2014-04-16