5-carboxypentyl (α-D-mannopyranosyl)-(1->3)-[(α-D-mannopyranosyl)-(1->6)]-α-D-mannopyranoside | 495390-50-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: 5-carboxypentyl (α-D-mannopyranosyl)-(1->3)-[(α-D-mannopyranosyl)-(1->6)]-α-D-mannopyranoside
• CAS: 495390-50-6
• 化学式: C₂₄H₄₂O₁₈
• 分子量: 618.587
• InChiKey: KELUMLQMJLFHBX-BPYOLWQNSA-N

物化性质

• 沸点：
  958.0±65.0 °C(Predicted)
• 密度：
  1.63±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  5-carboxypentyl (α-D-mannopyranosyl)-(1->3)-[(α-D-mannopyranosyl)-(1->6)]-α-D-mannopyranoside 在 碳酸氢钠 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 、 水 为溶剂， 反应 24.0h， 生成 5-[carboxy-2-(1,2-dihexadecanoyl-sn-glycero-3-phospho)ethanolamido]pentyl (α-D-mannopyranosyl)-(1->3)-[(α-D-mannopyranosyl)-(1->6)]-α-D-mannopyranoside sodium salt
  参考文献：
  名称：

  New mannotriosides and trimannosides as potential ligands for mannose-specific binding proteins

  摘要：

  α-D-甘露聚糖和3,6-二-O-(α-D-甘露聚糖)-α-D-甘露聚糖新糖脂3-6以及分支和集群三甘露糖酸38和41已经制备，用于研究脂质体作为抗原运输体到树突状细胞的研究。关键词：甘露三糖，三甘露糖，新糖脂共轭物，糖脂，合成。

  DOI：

  10.1139/v02-120
• 作为产物：
  描述：

  5-(methoxycarbonyl)pentyl (α-D-mannopyranosyl)-(1->3)-[(α-D-mannopyranosyl)-(1->6)]-α-D-mannopyranoside 在 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 24.0h， 以96%的产率得到5-carboxypentyl (α-D-mannopyranosyl)-(1->3)-[(α-D-mannopyranosyl)-(1->6)]-α-D-mannopyranoside
  参考文献：
  名称：

  New mannotriosides and trimannosides as potential ligands for mannose-specific binding proteins

  摘要：

  α-D-甘露聚糖和3,6-二-O-(α-D-甘露聚糖)-α-D-甘露聚糖新糖脂3-6以及分支和集群三甘露糖酸38和41已经制备，用于研究脂质体作为抗原运输体到树突状细胞的研究。关键词：甘露三糖，三甘露糖，新糖脂共轭物，糖脂，合成。

  DOI：

  10.1139/v02-120

文献信息

• The synthesis and immune stimulating action of mannose-capped lysine-based dendrimers
  作者：Ben W. Greatrex、Samuel J. Brodie、Richard H. Furneaux、Sarah M. Hook、Warren T. McBurney、Gavin F. Painter、Thomas Rades、Phillip M. Rendle

  DOI：10.1016/j.tet.2009.02.018

  日期：2009.4

  The syntheses of monodisperse lysine dendrimers, capped with two to sixty-four mono-, di- and tri-alpha-D-mannopyranosyl residues are described. These syntheses used reactive N-hydroxysuccinimide esters to ensure complete reaction of dendrimer amines with the mannosylating reagents. The purities of the dendrimers were established by RP-HPLC and MALDI-TOF mass spectrometry and were found to be excellent. The relative ability of these glycodendrimers to induce dendritic cell Maturation was measured, however, no significant trends were observed. (C) 2009 Elsevier Ltd. All rights reserved.