[6aR,9S,10aS]-9-[4,4-Bis-(4-methoxy-phenyl)-piperidin-1-ylmethyl]-5-bromo-10a-methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline | 288389-10-6

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 6,7-苯并吗啡烷
• 英文名称: [6aR,9S,10aS]-9-[4,4-Bis-(4-methoxy-phenyl)-piperidin-1-ylmethyl]-5-bromo-10a-methoxy-7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline
• 英文别名: (6aR,9S,10aS)-9-[[4,4-bis(4-methoxyphenyl)piperidin-1-yl]methyl]-5-bromo-10a-methoxy-7-methyl-4,6,6a,8,9,10-hexahydroindolo[4,3-fg]quinoline
• CAS: 288389-10-6
• 化学式: C₃₆H₄₂BrN₃O₃
• 分子量: 644.652
• InChiKey: BIEDQHXPSGPUSO-YEKDXAMVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  50
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation
  申请人：——

  公开号：US20020002170A1

  公开（公告）日：2002-01-03

  The invention provides a compound of formula I 1 wherein R, X, Y 1 and Y 2 are as defined in the description, and a process for preparing them. The compounds of formula I are useful as pharmaceuticals.

  这项发明提供了I1式化合物，其中R、X、Y1和Y2如描述中所定义，并提供了制备它们的方法。I式化合物在制药方面有用。
• PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION
  申请人：Novartis AG

  公开号：EP1150971A1

  公开（公告）日：2001-11-07
• [EN] PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION<br/>[FR] DERIVES DE LA PIPERIDINE AND PIPERAZINE INHIBITEURS DE LA FORMATION DES FIBRILLES A beta
  申请人：NOVARTIS AG

  公开号：WO2000047571A1

  公开（公告）日：2000-08-17

  A compound of formula (I) wherein X is (II) or (III) wherein R' is a group (a), R is a group (e) or (f) wherein n is 0 to 3. In particular the agents of the invention inhibit the formation of β-amyloid (Aβ) peptide into neurotoxic fibrils, thereby acting to prevent or slow down the accumulation of amyloid protein deposits in the brain.