N-[(S)-1-(4-fluorophenyl)-2-methylpropyl]-1-[(4-fluorophenyl)sulfonyl]-N-[2-(4-fluoropiperidin-1-yl)ethyl]cyclopropanecarboxamide | 1414775-37-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: N-[(S)-1-(4-fluorophenyl)-2-methylpropyl]-1-[(4-fluorophenyl)sulfonyl]-N-[2-(4-fluoropiperidin-1-yl)ethyl]cyclopropanecarboxamide
• 英文别名: N-[(1S)-1-(4-fluorophenyl)-2-methylpropyl]-1-(4-fluorophenyl)sulfonyl-N-[2-(4-fluoropiperidin-1-yl)ethyl]cyclopropane-1-carboxamide
• CAS: 1414775-37-3
• 化学式: C₂₇H₃₃F₃N₂O₃S
• 分子量: 522.632
• InChiKey: GSMSBKZYJVJWJW-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Amine Derivatives as Potassium Channel Blockers
  申请人：Harvey Andrew

  公开号：US20140336198A1

  公开（公告）日：2014-11-13

  The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

  本发明涉及用于调节细胞中钾通道活性的化合物，特别是用于调节T细胞中发现的Kv1.3通道活性的化合物。本发明还涉及使用这些化合物治疗或预防自身免疫和炎症性疾病，包括多发性硬化症，含有这些化合物的制药组合物以及它们的制备方法。
• AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS
  申请人：Bionomics Limited

  公开号：US20170088519A1

  公开（公告）日：2017-03-30

  The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.
• US9493451B2
  申请人：——

  公开号：US9493451B2

  公开（公告）日：2016-11-15
• US9914702B2
  申请人：——

  公开号：US9914702B2

  公开（公告）日：2018-03-13