K7Z22L25QC | 2988551-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: K7Z22L25QC
• 英文别名: 9-[2-(2,5-difluorophenyl)ethyl]-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
• CAS: 2988551-55-7
• 化学式: C₁₉H₂₆F₂N₂O₂
• 分子量: 352.4
• InChiKey: KALIKXMQWFLZKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] ALKYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN<br/>[FR] DÉRIVÉS ALKYLES DE COMPOSÉS DE 1-OXA-4,9-DIAZASPIRO-UNDÉCANE AYANT UNE ACTIVITÉ MULTIMODALE CONTRE LA DOULEUR
  申请人：ESTEVE LABOR DR

  公开号：WO2015185209A1

  公开（公告）日：2015-12-10

  The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及具有对σ受体和μ-阿片受体双重药理活性的化合物，更具体地涉及具有这种药理活性的二氮杂螺烷化合物，以及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗中的使用，特别是用于疼痛治疗。
• [EN] DEUTERATED DERIVATIVES OF 9-(2,5-DIFLUOROPHENETHYL)-4-ETHYL-2-METHYL-1-OXA-4,9-DIAZASPIRO[5.5]UNDECAN-3-ONE<br/>[FR] DÉRIVÉS DEUTÉRÉS DE 9-(2,5-DIFLUOROPHÉNÉTHYL)-4-ÉTHYL-2-MÉTHYL-1-OXA-4,9-DIAZASPIRO[5.5]UNDÉCAN-3-ONE
  申请人：ESTEVE PHARMACEUTICALS SA

  公开号：WO2019158634A1

  公开（公告）日：2019-08-22

  The present invention relates to deuterated derivatives of 9-(2,5-difluorophenethyl)-4- ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one having pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及具有药理活性的9-(2,5-二氟苯乙基)-4-乙基-2-甲基-1-氧-4,9-二氮杂螺[5.5]十一烷-3-酮的氘代衍生物，以及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗中的使用，特别是用于疼痛治疗。
• Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
  申请人：LABORATORIOS DEL DR. ESTEVE S.A.

  公开号：US10246465B2

  公开（公告）日：2019-04-02

  The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及对σ受体和μ-阿片受体具有双重药理活性的化合物，特别是具有这种药理活性的二氮杂螺十一烷化合物，涉及这种化合物的制备工艺，涉及含有这种化合物的药物组合物，还涉及它们在治疗中的用途，特别是用于治疗疼痛。
• Salts of (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
  申请人：ESTEVE PHARMACEUTICALS, S.A.

  公开号：US11236110B2

  公开（公告）日：2022-02-01

  The present invention relates to (R)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one salts, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of sigma receptor and/or μ-opioid receptor associated disease.

  本发明涉及(R)-9-(2,5-二氟苯乙基)-4-乙基-2-甲基-1-氧杂-4,9-二氮杂螺[5.5]十一烷-3-酮盐、包含它们的药物组合物，以及它们在治疗和/或预防σ受体和/或μ-阿片受体相关疾病中的用途。
• ALKYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
  申请人：Laboratorios del Dr. Esteve, S.A.

  公开号：EP3149006A1

  公开（公告）日：2017-04-05