2'-Desoxy-2'-fluoruridin-3'-phosphat | 61016-74-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐
• 英文名称: 2'-Desoxy-2'-fluoruridin-3'-phosphat
• 英文别名: 2'-fluoro-2'-deoxy-[3']uridylic acid；2'-Fluoro-2'-deoxyuridine 3'-monophosphate；[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate
• CAS: 61016-74-8
• 化学式: C₉H₁₂FN₂O₈P
• 分子量: 326.175
• InChiKey: IFIXUMAFUNKIAA-XVFCMESISA-N

物化性质

• 密度：
  1.81±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  146
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• [EN] COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE<br/>[FR] COMPOSITIONS ET MÉTHODES PERMETTANT D'INHIBER L'EXPRESSION DU GÈNE ALAS1
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2017048843A1

  公开（公告）日：2017-03-23

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.

  该发明涉及针对ALAS1基因的双链核糖核酸(dsRNA)组合物，以及使用这种dsRNA组合物来改变(ALAS1)表达的方法（例如，抑制）。
• Compositions and methods for inhibiting expression of the ALAS1 gene
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US10119143B2

  公开（公告）日：2018-11-06

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.

  本发明涉及靶向 ALAS1 基因的双链核糖核酸（dsRNA）组合物，以及使用这种 dsRNA 组合物改变（如抑制）ALAS1 表达的方法。
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：EP3052628B1

  公开（公告）日：2020-02-26
• Methods for collecting and detecting oligonucleotides
  申请人：Allen Paul G.

  公开号：US20090311269A1

  公开（公告）日：2009-12-17

  Methods, pharmaceutical compositions, and kits are provided which includes accurately sampling a RNA from a tissue of an animal and analyzing RNA in the tissue of the animal as an indicator of physiological state, infectious disease, neoplastic disease, autoimmune disease, inflammatory disease, cardiovascular disease, atherosclerotic disease, or neurological disease in the animal. A method is provided which includes administering at least one compound to an animal wherein the at least one compound is configured to prevent the cleavage of at least one tissue RNA by a ribonuclease. The method further includes collecting a sample of at least a portion of tissue from the animal.
• Methods, compositions, and kits for collecting and detecting oligonucleotides
  申请人：Allen Paul G.

  公开号：US20090311270A1

  公开（公告）日：2009-12-17

  Methods, pharmaceutical compositions, and kits are provided which includes accurately sampling a RNA from a tissue of an animal and analyzing RNA in the tissue of the animal as an indicator of physiological state, infectious disease, neoplastic disease, autoimmune disease, inflammatory disease, cardiovascular disease, atherosclerotic disease, or neurological disease in the animal. A method is provided which includes administering at least one compound to an animal wherein the at least one compound is configured to prevent the cleavage of at least one tissue RNA by a ribonuclease. The method further includes collecting a sample of at least a portion of tissue from the animal.