8-(4-Chlorobutyl)-8-azaspiro[4.5]decane | 130305-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 8-(4-Chlorobutyl)-8-azaspiro[4.5]decane
• CAS: 130305-66-7
• 化学式: C₁₃H₂₄ClN
• 分子量: 229.79
• InChiKey: PAOHJLYLSPDIAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Arylpiperidine derivatives
  申请人：PFIZER INC.

  公开号：EP0372776A2

  公开（公告）日：1990-06-13

  A series of novel N-alkyl or oxyalkyl arylpiperidine derivatives have been prepared, including their pharmaceutically acceptable acid addition salts, wherein the N-alkyl or oxyalkyl side chain is further substituted by certain aryl or heterocyclic ring groups. These particular compounds are useful in therapy as neuroleptic agents for the control of various psychotic disorders. Typical and preferred member compounds include 4-4-4-(2-­methoxyphenyl)-1-piperidinyl]ethyl}phenyl}}thiazole-2-­amine, 4-4-4-[4-(2-methoxyphenyl)-1-piperidinyl]-n-­butyl}phenyl}}thiazole-2-amine, 3-4-[4-(2-methoxy­phenyl)-1-piperidinyl]-n-butyl}-1,8,8-trimethyl-3-­azabicyclo[3.2.1]heptane-2,4-dione, 5-2-[4-(2-methoxy­phenyl)-1-piperidinyl]ethyl}oxindole and 3-2-[4-(1-­naphthyl)-1-piperidinyl]ethyl}2-methyl-4H-pyrido­[1,2-a]pyrimidine-4-one, respectively. Methods for preparing all these compounds from known starting materials are provided.

  现已制备出一系列新型 N-烷基或氧烷基芳基哌啶衍生物，包括其药学上可接受的酸加成盐，其中 N-烷基或氧烷基侧链进一步被某些芳基或杂环基团取代。这些特殊化合物可作为神经安定剂用于治疗，控制各种精神障碍。典型和优选的成员化合物包括 4-4-4-(2-甲氧基苯基)-1-哌啶基]乙基}苯基}噻唑-2-胺、4-4-4-[4-(2-甲氧基苯基)-1-哌啶基]-正丁基}苯基}噻唑-2-胺、3-4-[4-(2-甲氧基苯基)-1-哌啶基]-正丁基}-1,8,8-三甲基-3-氮杂双环[3.2.1]庚烷-2,4-二酮、5-2-[4-（2-甲氧基苯基）-1-哌啶基]乙基}氧化吲哚和 3-2-[4-（1-萘基）-1-哌啶基]乙基}2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮。本文提供了用已知起始原料制备所有这些化合物的方法。
• [EN] ARYLPIPERIDINE DERIVATIVES
  申请人：——

  公开号：WO1990006303A1

  公开（公告）日：1990-06-14

  [FR] On a préparé une série de nouveaux dérivés N-alkyle ou oxyalkyle arylpiperidine, comprenant leurs sels d'addition acides pharmaceutiquement acceptables, dans lesquels le chaîne latérale N-alkyle ou oxyalkyle est remplacée par certains groupes annulaires aryle ou hétérocycliques. Ces composés particuliers sont utiles en thérapie en tant qu'agents neuroleptiques pour traiter de divers troubles psychotiques. Les composés constitutifs habituels et préférés comprennent respectivement 4-4-2-[4-(2-méthoxyphényle)-1-piperidinyle]ethyl}phenyle}}thiazole-2-amine, 4-4-4-[4-(2-méthoxyphényle)-1-piperidinyle]-n-butyle}phenyle}}thiazole-2-amine, 3-4-[4-(2-méthoxyphenyle)-1-piperidinyle]-n-butyl}-1,8,8-triméthyle-3-azabicyclo[3.2.1] octane-2,4-dione, 5-2-[4-(2-méthoxyphenyle)-1-piperidinyle]ethyl}oxindole and 3-2-[4-(1-naphthyle)-1-piperidinyle]ethyle}-2-méthyle-4H-pyrido-[1,2-a]pyrimidine-4-one. On a mis au point des procédés de préparation de tous ces composés à partir de matières de départ.
  [EN] A series of novel N-alkyl or oxyalkyl arylpiperidine derivatives have been prepared, including their pharmaceutically acceptable acid addition salts, wherein the N-alkyl or oxyalkyl side chain is further substituted by certain aryl or heterocyclic ring groups. These particular compounds are useful in therapy as neuroleptic agents for the control of various psychotic disorders. Typical and preferred member compounds include 4-4-2-[4-(2-methoxyphenyl)-1-piperidinyl]ethyl}phenyl}}thiazole-2-amine, 4-4-4-[4-(2-methoxyphenyl)-1-piperidinyl]-n-butyl}phenyl}}thiazole-2-amine, 3-4-[4-(2-methoxyphenyl)-1-piperidinyl]-n-butyl}-1,8,8-trimethyl-3-azabicyclo[3.2.1]octane-2,4-dione, 5-2-[4-(2-methoxyphenyl)-1-piperidinyl]ethyl}oxindole and 3-2-[4-(1-naphthyl)-1-piperidinyl]ethyl}-2-methyl-4H-pyrido-[1,2-a]pyrimidine-4-one, respectively. Methods for preparing all these compounds from known starting materials are provided.