tert-butyl 3-methyl-3-(4-((4aS,8aS)-3-oxo-2H-benzo[b][1,4]oxazin-4(3H,4aH,5H,6H,7H,8H,8aH)-yl)piperidin-1-yl)pyrrolidine-1-carboxylate | 1185733-17-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: tert-butyl 3-methyl-3-(4-((4aS,8aS)-3-oxo-2H-benzo[b][1,4]oxazin-4(3H,4aH,5H,6H,7H,8H,8aH)-yl)piperidin-1-yl)pyrrolidine-1-carboxylate
• 英文别名: tert-butyl 3-[4-[(4aS,8aS)-3-oxo-4a,5,6,7,8,8a-hexahydrobenzo[b][1,4]oxazin-4-yl]piperidin-1-yl]-3-methylpyrrolidine-1-carboxylate
• CAS: 1185733-17-8
• 化学式: C₂₃H₃₉N₃O₄
• 分子量: 421.58
• InChiKey: JNMATHIHGJMKEI-GVLQVIKUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  62.3
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF 177
  申请人：Cheng Yun-Xing

  公开号：US20090221567A1

  公开（公告）日：2009-09-03

  Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein Y, X, A, R 1 , R 2 , m, p, and q are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  式I的化合物，或其药用可接受的盐：其中Y、X、A、R1、R2、m、p和q的定义如规范中所述，以及包括这些化合物的盐和药物组合物已经准备好。它们在治疗中很有用，特别是在疼痛管理中。
• [EN] MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF 177<br/>[FR] AGONISTES DES RÉCEPTEURS MUSCARINIQUES, COMPOSITIONS, PROCÉDÉS DE TRAITEMENT ET PROCÉDÉS DE PRÉPARATION ASSOCIÉS
  申请人：ASTRAZENECA AB

  公开号：WO2009108117A1

  公开（公告）日：2009-09-03

  Compounds of Formula I, or pharmaceutically acceptable salts thereof:wherein Y, X, A, R1, R2, m, p, and q are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.