2'-amino-2'-deoxyuridine 3'-monophosphate | 34407-65-3

分子结构分类

有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐

中文名称

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中文别名

——

英文名称

2'-amino-2'-deoxyuridine 3'-monophosphate

英文别名

2'-Amino-2'-deoxyuridin-3'-phosphat；2'-amino-2'-deoxy-[3']uridylic acid

2'-amino-2'-deoxyuridine 3'-monophosphate化学式

CAS

34407-65-3

化学式

C₉H₁₄N₃O₈P

mdl

——

分子量

323.199

InChiKey

PJENWIPZFANLJO-XVFCMESISA-N

BEILSTEIN

——

EINECS

——

反应信息

作为产物：

描述：

5'-O-(4,4'-dimethoxytrityl)-2'-(trifluoroacetamido)-2'-deoxyuridine 3'-O-(β-cyanoethyl N,N-diisopropylphosphoramidite) 生成 2'-amino-2'-deoxyuridine 3'-monophosphate

参考文献：

名称：

含硫和氨基修饰的磷酸二尿嘧啶酯类似物的合成和性质。

摘要：

为了研究为什么用2'-氨基取代2'-羟基会阻止水解，合成了磷酸二尿苷（UpU）的几种类似物。设计这些类似物以研究2'-取代基和5'-离去基团对水解速率的影响。所有类似物都比UpU对酸碱催化的水解更加不稳定。在6到9的pH范围内，尿嘧啶（3'-5'）5'-硫代5'-脱氧尿苷（UpsU）的水解速率以对数线性方式从5 x 10的值上升。（-）（6）s（-）（1）在pH 6到3200 x 10（-）（6）s（-）（1）在pH 9时，表明2'-氧代阴离子对磷的攻击在水解机理中是限速的。相反，尿酸（3'-5'）5'-氨基-5'的比率 -脱氧尿苷（UpnU）水解从pH 5的1802 x 10（-）（6）s（-）（1）降至pH 7.5的140 x 10（-）（6）s（-）（1），在高达11.5的pH值下保持恒定，因此表明是酸催化的反应。与amUpT的水解稳定性相反，类似物2'-氨基-2'-脱氧尿苷（3

DOI：

10.1021/jo960795l

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腺苷-3’-磷酸胸苷酰-(3'-5')-胸苷氰基乙基磷酰三酯胸腺嘧啶脱氧核苷3-单磷酸铵盐水合物胞啶-3'-单磷酸二钠盐环(腺苷酰(3'-5')尿苷单磷酸酯) 尿苷酸尿苷溴乙酰甲醇5'-二磷酸酯尿苷氯乙酰甲醇5'-二磷酸酯丁二酸,甲基-,1-(苯基甲基)酯,(2R)-(9CI) [(2R,3S,4R,5R)-5-(6-氨基嘌呤-9-基)-4-羟基-2-(羟基甲基)四氢呋喃-3-基]苯基磷酸氢酯 [(2R,3S,4R,5R)-5-(2-氨基-6-氧代-3H-嘌呤-9-基)-2-[(2-甲酰基苯氧基)甲基]-4-羟基四氢呋喃-3-基]磷酸二氢酯 N-苯甲酰基-2'-脱氧-3'-胞苷酸2-氯苯基2-氰基乙基酯 8-[(E)-苄亚基氨基]-2'-脱氧腺苷3'-(磷酸二氢酯) 5-甲基-2'-脱氧胞苷-3'-磷酸 3'-(二氢磷酸)鸟嘌呤核苷 3'-(1-丁基磷酰)腺苷 2ˊ-脱氧胞苷-3ˊ-一磷酸 2-脱氧腺苷-3-单磷酸酯*铵 2'-脱氧鸟苷 3'-(磷酸二氢酯) 2'-脱氧腺苷酰-(3'-5')-2'-脱氧腺苷酰-(3'-5)-2'-脱氧腺苷 2'-脱氧-3'-胞苷酸二钠盐 2' -脱氧3' -磷酸游离酸 [3']thymidylic acid mono-[4-(2-iodo-acetylamino)-phenyl] ester 5-Fluor-1-β-D-arabinofuranosylcytosin-3'-phosphat [3']thymidylic acid mono-[4-(2-bromo-acetylamino)-phenyl] ester O^2'-Methylguanosin-3'-phosphorsaeure uridine-3'-(2-cyanoethyl)phosphate [3']thymidylic acid mono-[4-(2-chloro-acetylamino)-phenyl] ester (1R)-1-(6-amino-purin-9-yl)-O³-phosphono-1,5-anhydro-D-glucitol Thymidin-3'-(2,4-dinitrophenyl)phosphat N⁴-Dimethylamino-methylen-2',5'-bis-O-(1-ethoxy-ethyl)-cytidin-3'-phosphat (2R)-3-((hydroxy(((2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)oxy)phosphoryl)oxy)propane-1,2-diyl dioleate 3-Methyl-uridin-3'-phosphat 2'-O-(tert-butyldimethylsilyl)inosine 3'-(allyl 2-cyanoethylphosphate) 2'-O-(2-tetrahydrofuranyl)-N4-(4-anisoyl)cytidine-3'-(2-chlorophenoxy)phosphoryl-2'-O-(2-tetrahydrofuranyl)-N4-(4-anisoyl)cytidine-3'-(2-chlorophenoxy)phosphoryl-2'-O-(2-tetrahydrofuranyl)-N4-(4-anisoyl)cytidine-3'-(2-chlorophenoxy)phosphoryl-2'-O-(2-tetrahydrofuranyl)-N4-(4-anisoyl)cytidine-3'-[O-(2-cyanoethyl)(2-chlorophenyl)phosphate] Phosphoric acid mono-[(2S,5R)-5-(2,4-diamino-pyrrolo[2,3-d]pyrimidin-7-yl)-2,5-dihydro-furan-2-ylmethyl] ester; compound with triethyl-amine 9-β.D-Glucopyranosyl-adenin-4'-phosphat 4-Oxo-pentanoic acid (2R,3S,5R)-3-[(2-chloro-phenoxy)-hydroxy-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester N(4),O(2')-Dibenzoyl-cytidin-3'-phosphat cis-((5-((4-amino-2-oxopyrimidin-1(2H)-yl)methyl)-1,3-oxathiolan-2-yl)methyl) (2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl hydrogen phosphate 1,20-(icosanedioxy)bis-(3'-phosphatidyl-2'-deoxythymidine) 4-N-benzoyl-5'-O-[di(2-cyanoethyloxy)phosphoryl]-2'-deoxycytidylyl-{3'-O^P-(2-cyanoethyl)->5'}-6-N-benzoyl-2',3'-di-O-(tert-butyldimethylsilyl)adenosine [3']uridylic acid mono-[1-(5,6-bis-ethoxycarbonylamino-pyrimidin-4-ylamino)-β-D-1-deoxy-ribofuranos-5-yl] ester 1-β-D-Arabinofuranosylcytidin-3'-phosphat OH[AA]AZMB

2'-amino-2'-deoxyuridine 3'-monophosphate | 34407-65-3

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