1'-[(5-methyl-1H-benzimidazol-2-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidine] | 1036405-88-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 1'-[(5-methyl-1H-benzimidazol-2-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidine]
• 英文别名: (6-methyl-1H-benzimidazol-2-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
• CAS: 1036405-88-5
• 化学式: C₂₁H₂₁N₃O₂
• 分子量: 347.417
• InChiKey: XXZVZUMZQYJRFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Spiro-piperidine derivatives
  申请人：Bissantz Caterina

  公开号：US20080161304A1

  公开（公告）日：2008-07-03

  The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I) wherein R 1 to R 5 , R 5 ′, X, Y and A are as defined in the specification.

  本发明涉及作为V1a受体拮抗剂的新颖螺环哌啶衍生物，其制备方法，含有它们的药物组合物以及它们作为药物的用途。本发明的活性化合物在预防和/或治疗焦虑和抑郁症等疾病方面是有用的。具体而言，本发明涉及一般式(I)的化合物，其中R1至R5，R5'，X，Y和A如规范中所定义。
• NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE
  申请人：Bissantz Caterina

  公开号：US20080167333A1

  公开（公告）日：2008-07-10

  The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I) wherein R 1 to R 5 , R 5′ , X, Y and A are as defined in the specification.

  本发明涉及新型螺环哌啶衍生物作为V1a受体拮抗剂，它们的制造、包含它们的药物组合物以及它们作为药物的用途。本发明的活性化合物在预防和/或治疗焦虑和抑郁症等疾病方面具有用处。特别是，本发明涉及一般式(I)中R1至R5，R5'，X，Y和A所定义的化合物。
• SPIRO-PIPERIDINE DERIVATIVES
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2125726A1

  公开（公告）日：2009-12-02
• US7501432B2
  申请人：——

  公开号：US7501432B2

  公开（公告）日：2009-03-10
• US7495008B2
  申请人：——

  公开号：US7495008B2

  公开（公告）日：2009-02-24