dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane

• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱土金属氧阴离子化合物
• 英文名称: dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane
• 化学式: Mg2O8Si3
• 分子量: 260.86
• InChiKey: GXGAKHNRMVGRPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.03
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  145
• 氢给体数：
  0
• 氢受体数：
  8

ADMET

毒理性

• 致癌性证据

评估：对于滑石粉在人类中的致癌性，证据不足。对于滑石粉在实验动物中的致癌性，证据也不足。总体评估：滑石粉不能被归类为对人类的致癌性（第3组）。

Evaluation: There is inadequate evidence in humans for the carcinogenicity of wollastonite. There is inadequate evidence in experimental animals for the carcinogenicity of wollastonite. Overall evaluation: Wollastonite cannot be classified as to its carcinogenicity to humans (Group 3).

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

纤维原性 - 引发组织损伤和纤维化（疤痕形成）。

Fibrogenic - Inducing tissue injury and fibrosis (scarring).

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 相互作用

一项体外研究表明，某些抗酸剂和吸附剂可能会降低两种广泛使用的抗疟疾药物氯喹和乙胺嘧啶的口服生物利用度。为了确定这些数据是否适用于临床（体内）情况，本研究在六名黑人-阿拉伯志愿者中跟踪了其中一种抗疟疾药物（氯喹）的血浆水平，既研究了单独给药的情况，也研究了与两种有相互作用的物质（三硅酸镁和陶土）分别给药的情况。这项体内工作证实了体外的研究结果；氯喹的血浆浓度-时间曲线下面积数据被三硅酸镁（降低了18.2%）和陶土（降低了28.6%）降低。可以预期乙胺嘧啶会有类似的结果。因此，建议为了避免药物损失，抗疟疾药物不应与这类胃肠药物同时服用，或者至少应间隔4小时以上给药，以减少它们在肠道中相互作用的风险，从而防止药物被抗酸剂/吸附剂吸附，并减少全身生物利用度的损失。

An in vitro study indicated that certain antacids and adsorbents may decrease the oral availability of the two widely used antimalarial agents chloroquine and pyrimethamine. To determine if this data was applicable to the clinical (in vivo) situation, plasma levels of one of the antimalarial agents (chloroquine) were followed in six Negro--Arab volunteers both when given alone and when taken with separate doses of two of the implicated interactants (magnesium trisilicate and kaolin). This in vivo work confirmed the in vitro findings; chloroquine area under the plasma concentration-time curve data were decreased by both magnesium trisilicate (18.2%) and kaolin (28.6%). Similar results could be expected for pyrimethamine. It is suggested therefore, to avoid loss of drug, that the antimalarials should not be taken with gastrointestinal medications of this type or that their administration should be separated by at least 4 h to reduce the risk of them interacting in the gut, thus preventing drug adsorption to the antacids/adsorbents, and loss of systemic availability.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

口服给药的甲氧苄啶的生物利用度的变异性由于镁三硅酸盐和高岭土-果胶的影响已被研究。甲氧苄啶在血液中的浓度是通过光谱荧光法在0、15和30分钟以及1、2、4和6小时测定的。当甲氧苄啶与镁三硅酸盐或高岭土-果胶同时给药时，其血液浓度曲线下的面积显著降低。镁三硅酸盐和高岭土-果胶处理组的甲氧苄啶最大血液浓度平均降低分别为49.94%和29.42%。数据表明，由于甲氧苄啶与这些药物的联合给药，可能会发生临床意义上的相互作用。

Variability in the bioavailability of orally administered trimethoprim due to magnesium trisilicate and kaolin-pectin has been investigated. The concentration of trimethoprim in blood was determined spectrofluorometrically at 0, 15 and 30 minutes and 1, 2, 4 and 6 hours. The area under the blood concentration curve of trimothoprim was significantly decreased, when the drug was given concurrently with magnesium trisilicate or kaolin-pectin. The mean decrease in maximum blood concentration of trimethoprim in magnesium trisilicate and kaolin-pectin treated groups was 49.94% and 29.42% respectively. The data suggest that a clinically significant interaction may occur due to concurrent administration of trimethoprim with these drugs.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

口服避孕药中使用的某些类固醇被镁三硅酸盐显著吸附。吸附亲和力遵循以下顺序：炔雌醇大于甲孕酮大于炔诺孕酮大于炔雌醇。在测试一种含有醋酸炔诺孕酮的避孕药片的过程中，介质中存在0.5%（w/v）的镁三硅酸盐，导致1小时后溶液中剩余类固醇的量几乎完全减少。

Some steroids used in oral contraceptives were adsorbed significantly by magnesium trisilicate. The adsorption affinity followed the sequence: ethindrone greater than mestranol greater than norethindrone greater than ethinyl estradiol. ...During the dissolution testing of a brand of contraceptive tablets containing norethindrone acetate, the presence of 0.5% (w/v) magnesium trisilicate in the medium resulted in almost complete reduction in the amount of the steroid remaining in solution after 1 hr.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

• 吸收

在胃中形成的硅酸化合物会进入肠道，在那里硅可以部分被吸收。

The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.

来源:DrugBank

吸收、分配和排泄

• 消除途径

从尿液中排出。

Excreted in the urine.

来源:DrugBank

吸收、分配和排泄

• 分布容积

胃中形成的硅酸二氢氧化物会进入肠道。

The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.

来源:DrugBank

吸收、分配和排泄

• 清除

最大镁清除率与肌酐清除率成正比。

Maximum magnesium clearance is directly proportional to creatinine clearance.

来源:DrugBank

吸收、分配和排泄

水合二氧化硅在胃中形成，然后进入肠道。硅可以被部分吸收，据报道，人类受试者尿液中大约7%的硅来自于三硅酸镁。

THE HYDRATED SILICON DIOXIDE...FORMED IN THE STOMACH, PASSES INTO THE INTESTINAL TRACT. SILICA CAN BE PARTLY ABSORBED & APPROX 7% OF THE SILICA OF MAGNESIUM TRISILICATE HAS BEEN REPORTED TO BE EXCRETED IN THE URINE OF HUMAN SUBJECTS.

来源:Hazardous Substances Data Bank (HSDB)