tert-butyl 5(S)-(((4,6-difluoropyrimidin-2-yl)amino)methyl)-6-azaspiro[2.5]octane-6-carboxylate | 1262396-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: tert-butyl 5(S)-(((4,6-difluoropyrimidin-2-yl)amino)methyl)-6-azaspiro[2.5]octane-6-carboxylate
• 英文别名: tert-butyl (7S)-7-[[(4,6-difluoropyrimidin-2-yl)amino]methyl]-6-azaspiro[2.5]octane-6-carboxylate
• CAS: 1262396-59-7
• 化学式: C₁₇H₂₄F₂N₄O₂
• 分子量: 354.4
• InChiKey: XRVXYVZSXKSJTR-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SPIRO AMINO COMPOUNDS SUITABLE FOR THE TREATMENT OF INTER ALIA SLEEP DISORDERS AND DRUG ADDICTION
  申请人：Stasi Luigi Piero

  公开号：US20120115882A1

  公开（公告）日：2012-05-10

  A spiro-amino compound of Formula (VI) wherein m is 1 or 2 or 3, n is 1 or 2, R is selected from a 5- or 6-membered aromatic ring and a 5- or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O and N, such ring being substituted with one or two substituents selected from the group consisting of (C 1 -C 3 )alkyl, halogen, (C 3 -C 5 )cycloalkyloxy, (C 1 -C 3 )alkylcarbonyl, phenyl optionally substituted with one or more halogen atoms, a 5- or 6-membered heterocycle comprising at least one nitrogen atom; P is a substituent Q or COQ, wherein Q is selected from the group consisting of phenyl, pyridyl, pyrimidyl, quinolyl, isoquinolyl, quinoxalyl, benzofuranyl, imidazotriazolyl, being such Q optionally substituted with one or more substituents selected from the group consisting of (C 1 -C 3 )alkyl, halogen, trifluoromethyl, carbammido, methylcarbammido, carboxy, methylcarboxy or a pharmaceutically acceptable salt thereof.

  式（VI）的螺环氨基化合物，其中m为1或2或3，n为1或2，R从5或6成员芳香环和5或6成员杂芳香环中选择，该环包含1到3个从S，O和N中选择的杂原子，该环被1或2个取代基所取代，所述取代基选择自(C1-C3)烷基，卤素，(C3-C5)环烷氧基，(C1-C3)烷基羰基，苯基，该苯基可选择一个或多个卤素原子进行取代，以及一种包含至少一个氮原子的5或6成员杂环；P是取代基Q或COQ，其中Q从苯基，吡啶基，嘧啶基，喹啉基，异喹啉基，喹嗪基，苯并呋喃基，咪唑三唑基中选择，所述Q可选择一个或多个取代基进行取代，所述取代基选择自(C1-C3)烷基，卤素，三氟甲基，氨基甲酰基，甲基氨基甲酰基，羧基，甲基羧基或其药学上可接受的盐。
• Spiro amino compounds suitable for the treatment of (inter alia) sleep disorders and drug addiction
  申请人：Rottapharm Biotech S.r.l.

  公开号：EP2454252B1

  公开（公告）日：2015-03-04
• US8859608B2
  申请人：——

  公开号：US8859608B2

  公开（公告）日：2014-10-14