9-Aza-spiro[5.6]dodecane | 51991-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 9-Aza-spiro[5.6]dodecane
• 英文别名: 9-Azaspiro[5.6]dodecane
• CAS: 51991-09-4
• 化学式: C₁₁H₂₁N
• mdl: MFCD20674169
• 分子量: 167.294
• InChiKey: ZWAATVZJDIHKSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] SMALL MOLECULE INHIBITOR OF CATHEPSIN C AND MEDICINAL USE THEREOF<br/>[FR] INHIBITEUR À PETITES MOLÉCULES DE LA CATHEPSINE C ET SON UTILISATION MÉDICINALE<br/>[ZH] 组织蛋白酶C小分子抑制剂及其医药用途
  申请人：REISTONE BIOPHARMA COMPANY LTD

  公开号：WO2022117059A1

  公开（公告）日：2022-06-09

  本公开涉及组织蛋白酶C小分子抑制剂及其医药用途。具体而言，本公开提供了一种式VI所示的酰胺腈类化合物、含有该化合物的药物组合物以及其抑制组织蛋白酶C的用途。
• INFLUENZA A VIRUS INHIBITION
  申请人：DeGrado William F.

  公开号：US20110294785A1

  公开（公告）日：2011-12-01

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
• US9464075B2
  申请人：——

  公开号：US9464075B2

  公开（公告）日：2016-10-11
• [EN] INFLUENZA A VIRUS INHIBITION<br/>[FR] INHIBITION DU VIRUS DE LA GRIPPE A
  申请人：UNIV PENNSYLVANIA

  公开号：WO2010033340A1

  公开（公告）日：2010-03-25

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.