5β-hydroxyskitanthine methiodide | 22325-01-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 5β-hydroxyskitanthine methiodide
• CAS: 22325-01-5
• 化学式: C₁₂H₂₄NO*I
• 分子量: 325.233
• InChiKey: NTXLLCBOHONKOV-LZNCIQFDSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.51
• 重原子数：
  15.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  5β-hydroxyskitanthine 、 碘甲烷 以 乙醚 为溶剂， 反应 3.0h， 以62%的产率得到5β-hydroxyskitanthine methiodide
  参考文献：
  名称：

  Isolation and pharmacological activities of the Tecoma stans alkaloids

  摘要：

  Tecoma stans is a plant traditionally used in Mexico for the control of diabetes. Amongst the alkaloids isolated from the plant harvested in Egypt, Tecomine was shown to be one of the compounds responsible for the hypoglycemic action. Given the interest in substances able to treat type II diabetes, we isolated the main alkaloids present in the plant growing in Egypt and Brazil and tested them in vivo on db/db mice. Contrary to previous literature reports on different animal models, Tecomine was unable to modify glycemia; the only effect seen being a decrease in plasma cholesterol levels. On the contrary, when tested in vitro on glucose uptake in white adipocytes, the compound showed a marked effect. The two other alkaloids isolated, namely 5beta-Hydroxyskitanthine, early called Base C, and Boschniakine were inactive both in vivo and in vitro assays.

  DOI：

  10.1016/s0014-827x(03)00133-2