Acetic acid (3E,9E)-(1R,2R,11R,14S)-16-benzyl-14-methyl-13-methylene-6,18-dioxo-17-aza-tricyclo[9.7.0.0^1,15]octadeca-3,9-dien-2-yl ester | 90741-87-0

分子结构分类

有机化合物 - 生物碱及其衍生物 - 细胞松弛素类

中文名称

——

中文别名

——

英文名称

Acetic acid (3E,9E)-(1R,2R,11R,14S)-16-benzyl-14-methyl-13-methylene-6,18-dioxo-17-aza-tricyclo[9.7.0.0^1,15]octadeca-3,9-dien-2-yl ester

英文别名

——

Acetic acid (3E,9E)-(1R,2R,11R,14S)-16-benzyl-14-methyl-13-methylene-6,18-dioxo-17-aza-tricyclo[9.7.0.0<sup>1,15</sup>]octadeca-3,9-dien-2-yl ester化学式

CAS

90741-87-0

化学式

C₂₈H₃₃NO₄

mdl

——

分子量

447.574

InChiKey

HPALKIAWHMMUAW-HBJWGNSTSA-N

BEILSTEIN

——

EINECS

——

反应信息

作为产物：

描述：

Acetic acid (3E,9E)-(1R,11S,14S)-16-benzyl-14-methyl-6,18-dioxo-13-trimethylsilanylmethyl-17-aza-tricyclo[9.7.0.0^1,15]octadeca-3,9,12-trien-2-yl ester 在 boron trifluoride diacetate 作用下，以二氯甲烷为溶剂，以80%的产率得到Acetic acid (3E,9E)-(1R,2R,11R,14S)-16-benzyl-14-methyl-13-methylene-6,18-dioxo-17-aza-tricyclo[9.7.0.0^1,15]octadeca-3,9-dien-2-yl ester

参考文献：

名称：

碳环细胞松弛素的全合成

摘要：

合成 a partir d'une 加成 Diels Alder de benzoyl-1 benzyl-5 chloroacetyl-3 pyrroline-3one-2 et de tributylsiloxy-1 trimethylsilylmethyl-6octriene-2,4,6

DOI：

10.1021/ja00328a053

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同类化合物

胞松弛素D 细胞松驰素J 细胞松驰素C 细胞松驰素 E 细胞松驰素 A 细胞松弛素H 细胞松弛素B 球毛壳菌素K 球毛壳菌素 F 球毛壳菌素 C 毛壳球菌素松胞菌素 F 曲霉菌素PZ 接柄孢素E 接柄孢素D 噻氯匹定N-氧化物二氢细胞松弛素 3-吡啶胺,6-乙氧基-4-甲基- (7S,13E,16S,18R,19E,21R)-7-乙酰氧基-18,21-二羟基-16,18-二甲基-10-苯基[11]松胞素-6(12),13,19-三烯-1,17-二酮 (7S,13E,16S,18R,19E,21R)-7,18,21-三羟基-16,18-二甲基-10-苯基-(11)松胞素-5,13,19-三烯-1-酮 (7S,13E,16S,18R,19E,21R)-21-(乙酰氧基)-7,18-二羟基-16,18-二甲基-10-苯基-(11)松胞素-5,13,19-三烯-1-酮 (6S,7S,13E,16S,18R,19E,21R)-21-(乙酰氧基)-6,7,18-三羟基-16,18-二甲基-10-苯基-(11)松胞素-13,19-二烯-1-酮 (3S,3aR,4S,6aS,7E,15aS)-3,3a,4,6a,9,10,13,14-八氢-4,5,8-三甲基-3-(2-甲基丙基)-1H-环十一碳(d)异吲哚-1,11,12,15(2H)-四酮 (3S,3aR,4S,6aS,7E,11S,13E,15aS)-2,3,3a,4,6a,9,10,11-八氢-11-羟基-4,5,8-三甲基-3-(2-甲基丙基)-1H-环十一碳(d)异吲哚-1,12,15-三酮 Acetic acid (3E,9E)-(1R,5R,7S,11R,14S,15R,16S)-16-benzyl-5-hydroxy-5,7,13,14-tetramethyl-6,12,18-trioxo-17-aza-tricyclo[9.7.0.0^1,15]octadeca-3,9-dien-2-yl ester Tetrahydro-cytochalasin C <4-³H>Cytochalasin B chaetoglobosin F_a 7,18-O-diacetylcytochalasin D 12-Hydroxyzygosporin G 12-cyanocytochalasin C 12-iodocytochalasin C 6,12-dibromocytochalasin D Engleromycin 12-bromocytochalasin C (7S,16S,17S,18R,21R,13E,19E)-17-hydroxy-16,18-dimethyl-10-phenyl<11>cytochalasa-6(12),13,19-triene-7,18,21-triyl triacetate (6R,7S,13E,16S,17R,18R)-2-Benzoyl-6,7,17,18-tetrahydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-13-ene-1,21-dione 17-hydroxycytochalasin N (7S,16S,18R,21R;13E,19E)-7,21-diacetoxy-5,6,18-trihydroxy-16,18-dimethyl-10-phenyl<11>cytochalasa-13,19-diene-1,17-dione isoaspochalasin C 7β,20α-dihydroxy-16α-methyl-10-phenyl-24-oxa-[14]cytochalasa-6(12),13t-diene-1,23-dione isocytochalasin N (7S,16S,18R,21R)-21-acetoxy-7-hydroxy-16,18-dimethyl-10-phenyl-18-(2-trimethylsilylethoxymethoxy)<11>cytochalasa-6(12),13t,19t-trien-1-one 7-O-Acetylcytochalasin N_pho (6R,7S,16S,18S)-6,7-epoxy-16,18-dimethyl-10-phenyl-18-(2-trimethylsilylethoxymethoxy)[11]cytochalas-13t-ene-1,21-dione (3S,3aR,4S,6S,6aR,10S,12S,15aR,E)-3-benzyl-4,10,12-trimethyl-5-methylene-6,12-bis((2-(trimethylsilyl)ethoxy)methoxy)-3,3a,4,5,6,6a,9,10,11,12,13,14-dodecahydro-1H-cycloundeca[d]isoindole-1,15(2H)-dione (7S,16S,18S)-7-hydroxy-16,18-dimethyl-10-phenyl-18-(2-trimethylsilylethoxymethoxy)<11>cytochalasa-6(12),13t-diene-1,21-dione 18,21-Dihydroxy-18,21-didesoxo-aspochalasin-B cytochalasin P 7,18-O-dibenzoate

Acetic acid (3E,9E)-(1R,2R,11R,14S)-16-benzyl-14-methyl-13-methylene-6,18-dioxo-17-aza-tricyclo[9.7.0.0^1,15]octadeca-3,9-dien-2-yl ester | 90741-87-0

分子结构分类

反应信息

同类化合物

相关结构分类

热门分子

Acetic acid (3E,9E)-(1R,2R,11R,14S)-16-benzyl-14-methyl-13-methylene-6,18-dioxo-17-aza-tricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl ester | 90741-87-0

分子结构分类

反应信息

同类化合物

相关结构分类

热门分子

Acetic acid (3E,9E)-(1R,2R,11R,14S)-16-benzyl-14-methyl-13-methylene-6,18-dioxo-17-aza-tricyclo[9.7.0.0^1,15]octadeca-3,9-dien-2-yl ester | 90741-87-0