[14C]-methyl paraoxon | 1254950-52-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: [14C]-methyl paraoxon
• CAS: 1254950-52-1
• 化学式: C₈H₁₀NO₆P
• 分子量: 251.122
• InChiKey: BAFQDKPJKOLXFZ-XPULMUKRSA-N

反应信息

• 作为产物：
  描述：

  [14C]-methyl parathion 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 [14C]-methyl paraoxon
  参考文献：
  名称：

  Thionate versus Oxon: Comparison of Stability, Uptake, and Cell Toxicity of (¹⁴CH₃O)₂-Labeled Methyl Parathion and Methyl Paraoxon with SH-SY5Y Cells

  摘要：

  The stability, hydrolysis, and uptake of the organophosphates methyl parathion and methyl paraoxon were investigated in SH-SY5Y cells. The stabilities of ((CH3O)-C-14)(2)-methyl parathion (C-14-MPS) and ((CH3O)-C-14)2-methyl paraoxon (C-14-MPO) at 1 mu M in culture media had similar half-lives of 91.7 and 101.9 h, respectively. However, 100 mu M MPO caused >95% cytotoxicity at 24 h, whereas 100 mu M MPS caused 4-5% cytotoxicity at 24 h (approximate to 60% cytotoxicity at 48 h). Greater radioactivity was detected inside cells treated with MPO as compared to MPS, although >80% of the total MPO uptake was primarily dimethyl phosphate (DMP). Maximum uptake was reached after 48 h of C-14-MPS or (CMPO)-C-14 exposure with total uptakes of 1.19 and 1.76 nM/10(6) cells for MPS and MPO, respectively. The amounts of MPS and MPO detected in the cytosol after 48 h of exposure time were 0.54 and 0.37 nM/10(6) cells, respectively.

  DOI：

  10.1021/jf100976v