5'-ethynylspiro[1-azabicyclo[2.2.2]octane-3,2'-(3'H)-furo[2,3-b]pyridine] | 220100-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 5'-ethynylspiro[1-azabicyclo[2.2.2]octane-3,2'-(3'H)-furo[2,3-b]pyridine]
• 英文别名: 5'-ethynylspiro[1-azabicyclo[2.2.2]octane-3,2'-3H-furo[2,3-b]pyridine]
• CAS: 220100-69-6
• 化学式: C₁₅H₁₆N₂O
• 分子量: 240.305
• InChiKey: MHQZPZAEOAZKDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Spiroazabicyclic heterocyclic compounds
  申请人：——

  公开号：US20030166935A1

  公开（公告）日：2003-09-04

  A compound of formula 1 wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

  本发明涉及一种化合物，其化学式为1，其中n、m、p、X、Y、W、A、G和D如规范中所定义，其对映体，其药学上可接受的盐，制备它们的方法，含有它们的组合物，以及它们在治疗中的用途，特别是在治疗或预防精神障碍和智力障碍方面的用途。
• New compounds
  申请人：——

  公开号：US20020187994A1

  公开（公告）日：2002-12-12

  A compound of formula 1 wherein n is 0 or 1; m is 0 or 1; p is 0 or 1; X is oxygen or sulfur; Y is CH, N or NO; W is oxygen, H 2 or F 2 ; A is N or C(R 2 ); G is N or C(R 3 ); D is N or C(R 4 ); with the proviso that no more than one of A, G, and D is nitrogen, but at least one of Y, A, G, and D is nitrogen or NO; R 1 is hydrogen or C 1 to C 4 alkyl; R 2 , R 3 , and R 4 are independently hydrogen, halogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, aryl, heteroaryl, OH, OC 1 -C 4 alkyl, CO 2 R 1 , —CN, —NO 2 , —NR 5 R 6 , —CF 3 , —OSO 2 CF 3 or R 2 and R 3 , or R 3 and R 4 respectively, may together form another six membered aromatic or heteroaromatic ring sharing A and G, or G and D, respectively, containing between zero and two nitrogen atoms, and substituted with one to two of the following substituents: independently hydrogen, halogen, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, aryl, heteroaryl, OH, OC 1 -C 4 alkyl, CO 2 R 1 , —CN, —NO 2 , —NR 5 R 6 , —CF 3 , —OSO 2 CF 3 ; R 5 and R 6 are independently hydrogen, C 1 -C 4 alkyl, C(O)R 7 , C(O)NHR 8 , C(O)OR 9 , SO 2 R 10 or may together be (CH 2 ) j Q(CH 2 ) k where Q is O, S, NR 11 , or a bond; j is 2 to 7, k is 0 to 2; R 7 , R 8 , R 9 , R 10 , and R 11 are independently C 1 -C 4 alkyl, aryl, or heteroaryl, or an enantiomer thereof, and the pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

  化合物的化学式为1，其中n为0或1；m为0或1；p为0或1；X为氧或硫；Y为CH、N或NO；W为氧、H2或F2；A为N或C（R2）；G为N或C（R3）；D为N或C（R4）；但是A、G和D中最多只有一个是氮，但Y、A、G和D中至少有一个是氮或NO；R1为氢或C1到C4烷基；R2、R3和R4独立地为氢、卤素、C1-C4烷基、C2-C4烯基、C2-C4炔基、芳基、杂环芳基、OH、OC1-C4烷基、CO2R1、-CN、-NO2、-NR5R6、-CF3、-OSO2 或R2和R3，或R3和R4可以分别形成另一个共用A和G或G和D的六元芳香或杂芳香环，其中包含零到两个氮原子，并且取代有以下一个或两个取代基：独立地为氢、卤素、C1-C4烷基、C2-C4烯基、C2-C4炔基、芳基、杂环芳基、OH、OC1-C4烷基、CO2R1、-CN、- 、-NR5R6、- 、-OSO2 ；R5和R6独立地为氢、C1-C4烷基、C（O）R7、C（O）NHR8、C（O）OR9、SO2R10或可以共同为（CH2）jQ（ ）k，其中Q为O、S、NR11或键；j为2到7，k为0到2；R7、R8、R9、R10和R11独立地为C1-C4烷基、芳基或杂环芳基，或其对映体，以及其药学上可接受的盐，制备它们的过程，包含它们的组合物以及它们在治疗中的应用，特别是在治疗或预防精神障碍和智力障碍方面。
• Spiroazabicyclic Heterocyclic Compounds
  申请人：Phillips Eifion

  公开号：US20080153864A1

  公开（公告）日：2008-06-26

  A compound of formula wherein n, m, p, X, Y, W, A, G and D are as defined in the specification, enantiomers thereof, pharmaceutical compositions containing said compound, pharmaceutically acceptable salts thereof, its use in therapy, especially in the treatment of psychotic disorders and intellectual impairment disorders.

  一种化合物的化学式为式中n，m，p，X，Y，W，A，G和D在规范中定义，其对映异构体，含有该化合物的制药组合物，其药学上可接受的盐，其在治疗中的用途，特别是用于治疗精神疾病和智力障碍。
• Spiro [1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine for use in the treatment of psychotic and intellectual impairment disorders
  申请人：AstraZeneca AB

  公开号：EP1213291A1

  公开（公告）日：2002-06-12

  A compound spiro[1-azabicyclo[2.2.2]octane-3,2'-(3'H)-furo[2,3-b]pyridine] or an enantiomer thereof, and pharmaceutically acceptable salts thereof, processes for preparing them, composition containing them, and their use in therapy, especially in the treatment or prophylaxis of psychotic disorders and intellectual impairment disorders.

  一种化合物螺[1-氮杂双环[2.2.2]辛烷-3,2'-(3'H)-呋喃并[2,3-b]吡啶]或其对映体，及其药学上可接受的盐、制备工艺、含有它们的组合物，以及它们在治疗中的用途，特别是在治疗或预防精神障碍和智力障碍方面的用途。
• Treatment of fibromyalgia syndrome
  申请人：——

  公开号：US20040259909A1

  公开（公告）日：2004-12-23

  A method for treating fibromyalgia syndrome with an agonist of &agr;7 nicotinic acetylcholine receptors.

  一种用&agr;7烟碱乙酰胆碱受体激动剂治疗纤维肌痛综合征的方法。