| 1402090-91-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• CAS: 1402090-91-8
• 化学式: C₆₃H₇₆N₁₁O₂₆P₃Si
• 分子量: 1524.36
• InChiKey: OOOPJVPGVHJLRV-NPIDUEPFSA-N

反应信息

• 作为反应物：
  描述：

  在 氢氟酸 、 水 、 ammonium hydroxide 作用下， 以 乙腈 为溶剂， 反应 3.17h， 以44%的产率得到
  参考文献：
  名称：

  Furanose ring conformations in a 1′-alkynyl C-nucleoside and the dinucleotide

  摘要：

  A large-scale synthesis was carried out for alkynyl C-nucleotide oligomers in order to clarify the structural details of the artificial DNA. A liquid-phase synthesis by means of phosphoramidite methodology enabled us to handle similar to 0.1 g of the DNA oligomers possessing a pseudouracil derivative (T*) as a non-natural nucleobase. H-1 NMR measurements in aqueous media were carried out for the oligomers, succeeded in the accurate assignments of the protons accompanying with determination of the coupling constants (J values). These J values revealed that average conformation of the alkynylribose rings in the DNA was substantially biased toward the S-type conformers (T-2(1)/E-1/T-0(1)). X-ray crystal analysis of the non-natural nucleoside also supported the S-type conformation (E-2/T-2(1)) as seen in natural B-DNA. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.057
• 作为产物：
  描述：

  在 三氯乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Furanose ring conformations in a 1′-alkynyl C-nucleoside and the dinucleotide

  摘要：

  A large-scale synthesis was carried out for alkynyl C-nucleotide oligomers in order to clarify the structural details of the artificial DNA. A liquid-phase synthesis by means of phosphoramidite methodology enabled us to handle similar to 0.1 g of the DNA oligomers possessing a pseudouracil derivative (T*) as a non-natural nucleobase. H-1 NMR measurements in aqueous media were carried out for the oligomers, succeeded in the accurate assignments of the protons accompanying with determination of the coupling constants (J values). These J values revealed that average conformation of the alkynylribose rings in the DNA was substantially biased toward the S-type conformers (T-2(1)/E-1/T-0(1)). X-ray crystal analysis of the non-natural nucleoside also supported the S-type conformation (E-2/T-2(1)) as seen in natural B-DNA. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.057