6-carboxymethylthio-6-deoxy-α-cyclodextrin | 1252661-79-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: 6-carboxymethylthio-6-deoxy-α-cyclodextrin
• CAS: 1252661-79-2
• 化学式: C₃₈H₆₂O₃₁S
• 分子量: 1046.96
• InChiKey: FUJFNPZHZAZQKH-XOCJMAEKSA-N

反应信息

• 作为反应物：
  描述：

  6-carboxymethylthio-6-deoxy-α-cyclodextrin 、 6-deoxy-6-(L-histidylamino)-β-cyclodextrin 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 50.0h， 以77%的产率得到6-{N-[6-(6-deoxy-α-cyclodextrinylthio)acetyl]-L-histidylamino}-6-deoxy-β-cyclodextrin
  参考文献：
  名称：

  Homotropic cooperativity of cyclodextrin dimer as an artificial hydrolase

  摘要：

  Three kinds of cyclodextrin (CD) dimer (one homo-dimer of beta-CD and two types of hetero-dimer of alpha-CD and beta-CD) were synthesized as artificial hydrolases. The initial rates of the cleavage reaction of p-nitrophenyl methoxyethoxyethoxyacetate (8) by each of the three dimers were measured under the condition of excess of substrate at 25 degrees C in a pH 7.4 phosphate buffer solution. In a plot of initial rate against concentration of the substrate, the reaction with the homo-dimer (beta C beta H 5) gave a sigmoidal curve, whereas the reaction with either of the hetero-dimers gave a simple hyperbolic curve. Only beta C beta H 5 showed homotropic cooperativity, with a Hill constant of 1.8. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2010.06.005
• 作为产物：
  描述：

  methylthio-acetic acid sodium salt 、 6-monodeoxy-6-monoiodo-α-cyclodextrin 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 、 水 为溶剂， 反应 73.0h， 以36%的产率得到6-carboxymethylthio-6-deoxy-α-cyclodextrin
  参考文献：
  名称：

  Homotropic cooperativity of cyclodextrin dimer as an artificial hydrolase

  摘要：

  Three kinds of cyclodextrin (CD) dimer (one homo-dimer of beta-CD and two types of hetero-dimer of alpha-CD and beta-CD) were synthesized as artificial hydrolases. The initial rates of the cleavage reaction of p-nitrophenyl methoxyethoxyethoxyacetate (8) by each of the three dimers were measured under the condition of excess of substrate at 25 degrees C in a pH 7.4 phosphate buffer solution. In a plot of initial rate against concentration of the substrate, the reaction with the homo-dimer (beta C beta H 5) gave a sigmoidal curve, whereas the reaction with either of the hetero-dimers gave a simple hyperbolic curve. Only beta C beta H 5 showed homotropic cooperativity, with a Hill constant of 1.8. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2010.06.005