(2-methanesulfonyl-6-methyl-5-phenyl-furo[2,3-d]pyrimidin-4-yl)-pyridin-2-ylmethylamine | 1044711-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃[2,3-d]嘧啶
• 英文名称: (2-methanesulfonyl-6-methyl-5-phenyl-furo[2,3-d]pyrimidin-4-yl)-pyridin-2-ylmethylamine
• 英文别名: 6-methyl-2-methylsulfonyl-5-phenyl-N-(pyridin-2-ylmethyl)furo[2,3-d]pyrimidin-4-amine
• CAS: 1044711-40-1
• 化学式: C₂₀H₁₈N₄O₃S
• 分子量: 394.454
• InChiKey: VXOQDVUFBMPREB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] FURANOPYRIMIDINE COMPOUNDS EFFECTIVE AS POTASSIUM CHANNEL INHIBITORS<br/>[FR] COMPOSES DE FURANOPYRIMIDINE EFFICACES COMME INHIBITEURS DES CANAUX POTASSIQUES
  申请人：XENTION DISCOVERY LTD

  公开号：WO2005121149A1

  公开（公告）日：2005-12-22

  A compound of formula (I) wherein R1 is aryl, heteroaryl, cycloalkyl or alkyl; R2 is H, alkyl, nitro, -CO2R7, CONR4R5 or halo; R3 is H, NR4R5, NC(O)R8, halo, trifluoromethyl, alkyl, nitrile or alkoxy; R4 and R5 may be the same or different, and may be H, alkyl, aryl, heteroaryl or cycloalkyl; or R4 and R5 may together form a saturated, unsaturated or partially saturated 4 to 7 member ring, wherein said ring may optionally comprise one or more further heteroatoms selected from N, O or S; X is O, S or NR6; R6 is H or alkyl; R7 is hydrogen, methyl or ethyl; R8 is methyl or ethyl; Ll is (CH2)n, where n is 1,2 or 3; and Y is aryl, a heterocyclic group, alkyl, alkenyl or cycloalkyl; together with pharmaceutically acceptable salts thereof. The use of these compounds as potassium channel inhibitors is also described.

  式（I）的化合物，其中R1为芳基、杂环芳基、环烷基或烷基；R2为H、烷基、硝基、-CO2R7、CONR4R5或卤素；R3为H、NR4R5、NC（O）R8、卤素、三氟甲基、烷基、腈基或烷氧基；R4和R5可以相同也可以不同，可以是H、烷基、芳基、杂环芳基或环烷基；或者R4和R5可以共同形成饱和、不饱和或部分饱和的4到7成员环，其中该环可以选择性地包含一个或多个来自N、O或S的其他杂原子；X为O、S或NR6；R6为H或烷基；R7为氢、甲基或乙基；R8为甲基或乙基；Ll为（CH2）n，其中n为1、2或3；Y为芳基、杂环基、烷基、烯基或环烷基；以及其药学上可接受的盐。还描述了这些化合物作为钾通道抑制剂的用途。
• FURANOPYRIMIDINE COMPOUNDS EFFECTIVE AS POTASSIUM CHANNEL INHIBITORS
  申请人：Xention Limited

  公开号：EP1758909A1

  公开（公告）日：2007-03-07