磷酸-1-十三烷基醇酯钠盐 | 68647-24-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 磷酸-1-十三烷基醇酯钠盐
• 英文名称: 1-Tridecanol, phosphate, sodium salt
• 英文别名: disodium;tridecyl phosphate
• CAS: 68647-24-5
• 化学式: C13H27Na2O4P
• 分子量: 324.3
• InChiKey: IINDYWXDQHZLEZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.85
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• CHEMICALLY STABLE AND OROMUCOSALLY ABSORBABLE GEL COMPOSITIONS OF A PHARMACEUTICAL ACTIVE AGENT IN A MULTI-CHAMBERED DELIVERY SYSTEM
  申请人：MUCODEL PHARMA LLC

  公开号：US20160038406A1

  公开（公告）日：2016-02-11

  An oromucosally absorbable liquid composition for administration to a human patient comprises one liquid containing a pH-sensitive pharmaceutically active together with one or more optional suitable pharmaceutical excipients in a first compartment; and a second liquid at pH greater than 5 containing a buffer or alkaline components together with one or more optional suitable pharmaceutical excipients in a second distinct compartment; the first and second compartments maintaining separation of the first and second liquids during storage and allowing for mixing of the two liquids to form an oromucosally absorbable composition at the point of use

  一种可口服吸收的液体组合物，用于给人类患者使用，包括第一隔室中的一种液体，该液体含有一个pH敏感的药物活性成分，以及一个或多个可选的适宜的药物辅料；以及第二隔室中的一个pH大于5的液体，该液体含有缓冲剂或碱性成分以及一个或多个可选的适宜的药物辅料，第一和第二隔室在储存期间保持第一和第二液体的分离，并允许在使用时混合两种液体以形成可口服吸收的组合物。
• SYSTEM, METHOD AND DEVICE FOR TISSUE-BASED DIAGNOSIS
  申请人：The Regents of the University of California

  公开号：EP3073263A1

  公开（公告）日：2016-09-28

  The current invention provides devices, methods and systems involving application of energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, tissue decontamination as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types ofbiomolecules, drugs and microbes). In addition, the current invention provides specific compositions of the said liquefaction promoting medium so as to facilitate liquefaction, preserve liquefied tissue constituents, and enable delivery of molecules into tissues. Determination of tissue composition in the liquefied tissue sample can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications. The methods, devices and systems are used to deliver one or more drugs through or into the site of the tissue to be liquefied.

  本发明提供的装置、方法和系统涉及对相关组织施加能量和/或液化促进介质，以产生包含组织成分的液化样本，从而提供快速组织取样、组织净化以及定性和/或定量检测可能是组织成分一部分的分析物（例如，几种类型的生物大分子、药物和微生物）。此外，本发明还提供了上述液化促进介质的特定成分，以促进液化，保存液化的组织成分，并将分子输送到组织中。液化组织样本中组织成分的测定可用于多种应用，包括局部和全身性疾病的诊断或预后、评估给药后治疗药物在不同组织中的生物利用度、滥用药物的法医检测、评估暴露于有害制剂后组织微环境的变化以及其他各种应用。这些方法、装置和系统用于将一种或多种药物通过待液化组织的部位或进入该部位。
• Paste composition, heating element, heating apparatus, and method of manufacturing the paste composition
  申请人：Samsung Electronics Co., Ltd.

  公开号：US10316236B2

  公开（公告）日：2019-06-11

  A paste composition including: a carbon nanotube; a microemulsion adsorbed on a surface of the carbon nanotube, wherein the microemulsion includes a metal precursor and a surfactant; and an organic vehicle.

  一种糊状组合物，包括：碳纳米管；吸附在碳纳米管表面的微乳液，其中微乳液包括金属前体和表面活性剂；以及有机载体。
• Agricultural adjuvant compositions of oil/surfactant/salt emulsions and methods for use
  申请人：Rhodia Operations

  公开号：US10383328B2

  公开（公告）日：2019-08-20

  An adjuvant composition that contains (a) one or more anionic surfactant compounds, (b) one or more one or more fatty acid alkyl ester compounds, and (c) one or more salts is useful as a component of pesticide compositions.

  含有 (a) 一种或多种阴离子表面活性剂化合物、(b) 一种或多种脂肪酸烷基酯化合物和 (c) 一种或多种盐的佐剂组合物可用作杀虫剂组合物的成分。
• Compositions with permeation enhancers for drug delivery
  申请人：Children's Medical Center Corporation

  公开号：US11110175B2

  公开（公告）日：2021-09-07

  The present invention provides compositions and methods for delivery of therapeutic agents across an barrier. The compositions include a therapeutic agent (e.g., antimicrobial agent, antibiotic, or anesthetic agent), a permeation enhancer which increases the flux of the therapeutic agent across the barrier, and a matrix forming agent. The matrix forming agent forms a gel at a suitable gelation temperature and rheological properties for use in drug delivery, and in some cases, the gelation temperature and rheological properties are not significantly changed from those of the composition without the permeation enhancer. The invention also provides a matrix forming agent and compositions thereof. Such compositions are particularly useful in the treatment of otitis media. Methods of treatment, methods of delivery, and kits for the compositions described herein are also provided.

  本发明提供了跨屏障递送治疗剂的组合物和方法。这些组合物包括治疗剂（如抗菌剂、抗生素或麻醉剂）、增加治疗剂通过屏障的通量的渗透促进剂和基质形成剂。基质形成剂在合适的凝胶温度和流变特性下形成凝胶，用于给药，在某些情况下，凝胶温度和流变特性与不含渗透增强剂的组合物相比没有明显变化。本发明还提供了一种基质形成剂及其组合物。这种组合物特别适用于中耳炎的治疗。本发明还提供了用于本文所述组合物的治疗方法、给药方法和试剂盒。