3'-(2,5-dimethyphenyl)-quinuclidine-3-spiro-5'-oxazolidine-2',4'-dione trifluoroacetate salt | 917986-37-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 3'-(2,5-dimethyphenyl)-quinuclidine-3-spiro-5'-oxazolidine-2',4'-dione trifluoroacetate salt
• 英文别名: 3'-(2,5-dimethylphenyl)-quinuclidine-3-spiro-5'-oxazolidine-2',4'-dione trifluoroacetate；3-(2,5-Dimethylphenyl)spiro[1,3-oxazolidine-5,3'-1-azabicyclo[2.2.2]octane]-2,4-dione;2,2,2-trifluoroacetic acid
• CAS: 917986-37-9
• 化学式: C₂HF₃O₂*C₁₇H₂₀N₂O₃
• 分子量: 414.381
• InChiKey: QGDJPBXCMMNEOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.88
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Novel spiro-quinuclidinyl derivatives for the treatment of central nervous system disorders
  申请人：Huang Yifang

  公开号：US20070004715A1

  公开（公告）日：2007-01-04

  The present invention is directed to novel spiro-quinuclidinyl derivatives, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.

  本发明涉及新颖的螺环喹啉基衍生物，含有它们的药物组合物以及它们在治疗中枢神经系统疾病中的用途。
• [EN] NOVEL SPIRO-QUINUCLIDINYL DERIVATIVES FOR THE TREATMENT OF THE CENTRAL NERVOUS SYSTEM DISORDERS<br/>[FR] UTILISATION DE NOUVEAUX DÉRIVÉS SPIRO-QUINUCLIDINYLE DANS LE TRAITEMENT DES TROUBLES DU SYSTÈME NERVEUX CENTRAL
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2008073067A1

  公开（公告）日：2008-06-19

  [EN] The present invention is directed to novel spiro-quinuclidinyl derivatives, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
  [FR] Cette invention concerne de nouveaux dérivés spiro-quinuclidinyle, des compositions pharmaceutiques les renfermant et leur utilisation dans le traitement des troubles du système nerveux central.