磷酸异丁酯二甲酯 | 59259-33-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 中文名称: 磷酸异丁酯二甲酯
• 英文名称: phosphoric acid isobutyl ester dimethyl ester
• 英文别名: Phosphorsaeure-dimethyl-isobutylester；O,O-Dimethyl-O-isobutyl-phosphat；Dimethyl 2-methylpropyl phosphate
• CAS: 59259-33-5
• 化学式: C₆H₁₅O₄P
• 分子量: 182.156
• InChiKey: IJVSYQXKCIJGPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  磷酸异丁酯二甲酯 以 甲醇 为溶剂， 生成 Ammonium, (3-hydroxypropyl), trimethyl-, hydroxide, isobutyl hydrogen phosphate, innersalt
  参考文献：
  名称：

  Chabrier,P. et al., Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1968, vol. 267, p. 732 - 734

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁醇 、 氯磷酸二甲酯 生成 磷酸异丁酯二甲酯
  参考文献：
  名称：

  Lebedev, N. N.; Mamzurin, B. V.; Savel'yanov, V. P., Journal of general chemistry of the USSR, 1985, vol. 55, # 3, p. 482 - 485

  摘要：

  DOI：

文献信息

• Prodrugs of HIV reverse transcriptase inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：US10004740B2

  公开（公告）日：2018-06-26

  Compounds of Formula I are described: wherein R1 and R2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

  描述了式 I 的化合物：其中 R1 和 R2 在本文中定义。式 I 化合物可用于抑制 HIV 逆转录酶，预防和治疗 HIV 感染，以及预防、延缓艾滋病的发生或发展以及治疗艾滋病。这些化合物可用作药物组合物的成分，也可与其他抗病毒药物、免疫调节剂、抗生素或疫苗结合使用。
• Jentzsch,R. et al., Journal fur praktische Chemie (Leipzig 1954), 1975, vol. 317, p. 733 - 744
  作者：Jentzsch,R. et al.

  DOI：——

  日期：——
• FLÜSSIGE, PYRACLOSTROBIN-HALTIGE PFLANZENSCHUTZFORMULIERUNGEN
  申请人：BASF SE

  公开号：EP2346322A2

  公开（公告）日：2011-07-27
• Liquid Pyraclostrobin-Containing Crop Protection Formulations
  申请人：Troppmann Ulrike

  公开号：US20110195846A1

  公开（公告）日：2011-08-11

  The present invention relates to a novel liquid formulation for crop protection which comprises a) pyraclostrobin; b) at least one organic solvent S1 with a water solubility of less than 2 g/l at 20° C.; c) at least one organic solvent S2 with a water solubility of at least 2 g/l at 20° C., where S2 comprises at least one solvent S2.1 with a water solubility of more than 200 g/l at 20° C. and optionally at least one solvent S2.2 with a water solubility of 2 to 200 g/l at 20° C.; d) at least one anionic surface-active substance SA1; e) at least one nonionic surface-active substance SA2; and f) water. The invention also relates to the use of the crop protection formulation for treatment of plants and seed, and to corresponding methods.
• PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS
  申请人：BURGEY Christopher S.

  公开号：US20170173015A1

  公开（公告）日：2017-06-22

  Compounds of Formula I are described: wherein R 1 and R 2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV, and the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.