Adenosin-5'-sulfatopyrophosphat | 4241-77-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （5'->5'）-二核苷酸
• 英文名称: Adenosin-5'-sulfatopyrophosphat
• 英文别名: O^5'-(1,2-dihydroxy-2-sulfooxy-diphosphoryl)-adenosine；[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] sulfo hydrogen phosphate
• CAS: 4241-77-4
• 化学式: C₁₀H₁₅N₅O₁₃P₂S
• 分子量: 507.268
• InChiKey: ODRZERJFZYRDJN-KQYNXXCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  284
• 氢给体数：
  6
• 氢受体数：
  17

文献信息

• Mycobacterial sulfation pathway proteins and methods of use thereof
  申请人：——

  公开号：US20030104001A1

  公开（公告）日：2003-06-05

  Novel mycobacterial sulfation pathway enzymes and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting growth and/or virulence of a pathogenic mycobacterium, and methods of treating disease conditions associated with a pathogenic mycobacterium, particularly by administering an inhibitor of a mycobacterial sulfation pathway enzyme.

  本研究提供了新型分枝杆菌硫酸化途径酶和与之相关的多肽，以及编码它们的核酸组合物。所述多肽和核酸组合物可用于多种应用，包括研究、诊断和治疗剂筛选应用。本发明还提供了抑制致病分枝杆菌生长和/或毒力的方法，以及治疗与致病分枝杆菌相关疾病的方法，特别是通过施用分枝杆菌硫化途径酶抑制剂。
• Stress-regulated genes of plants, transgenic plants containing same, and methods of use
  申请人：Harper F. Jeffrey

  公开号：US20060183137A1

  公开（公告）日：2006-08-17

  Clusters of plant genes that are regulated in response to one or more stress conditions are provided, as are isolated plant stress-regulated genes, including portions thereof comprising a coding sequence or a regulatory element, and to consensus sequences comprising a plant stress-regulated regulatory element. In addition, a recombinant polynucleotide, which includes a plant stress-regulated gene, or functional portion thereof, operatively linked to a heterologous nucleotide sequence, is provided, as are transgenic plants, which contain a plant stress-regulated gene or functional portion thereof that was introduced into a progenitor cell of the plant. Also provided are methods of using a plant stress-regulated gene to confer upon a plant a selective advantage to a stress condition, methods of identifying an agent that modulates the activity of a plant stress-regulated regulatory element, and methods of determining whether a plant has been exposed to a stress.

  提供了针对一种或多种胁迫条件进行调控的植物基因簇，以及分离的植物胁迫调控基因，包括其中包含编码序列或调控元件的部分，以及包含植物胁迫调控元件的共识序列。此外，还提供了重组多核苷酸，其中包括与异源核苷酸序列操作性连接的植物胁迫调控基因或其功能部分，以及转基因植物，其中含有导入植物祖细胞的植物胁迫调控基因或其功能部分。此外，还提供了使用植物胁迫调控基因使植物对胁迫条件具有选择优势的方法、鉴定调节植物胁迫调控元件活性的制剂的方法，以及确定植物是否暴露于胁迫的方法。
• STRESS-REGULATED GENES OF PLANTS, TRANSGENIC PLANTS CONTAINING SAME, AND METHODS OF USE
  申请人：The Scripps Research Institute

  公开号：EP1313867A2

  公开（公告）日：2003-05-28
• MYCOBACTERIAL SULFATION PATHWAY PROTEINS AND METHODS OF USE THEREOF
  申请人：BERTOZZI Carolyn R.

  公开号：US20080175869A1

  公开（公告）日：2008-07-24

  Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting growth and/or virulence of a pathogenic mycobacterium, and methods of treating disease conditions associated with a pathogenic mycobacterium, particularly by administering an inhibitor of a mycobacterial sulfation pathway protein. The present invention further provides genetically modified mycobacteria having a defect in a sulfation pathway enzyme gene; and immunogenic compositions that include such genetically modified mycobacteria.
• US6858213B2
  申请人：——

  公开号：US6858213B2

  公开（公告）日：2005-02-22