(+/-)-decahydro-8-(-pyrrolidinyl)-quinoline | 122832-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉类
• 英文名称: (+/-)-decahydro-8-(-pyrrolidinyl)-quinoline
• 英文别名: 8-pyrrolidin-1-yl-1,2,3,4,4a,5,6,7,8,8a-decahydroquinoline
• CAS: 122832-37-5
• 化学式: C₁₃H₂₄N₂
• 分子量: 208.347
• InChiKey: SVFRRIUHIIRKFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-decahydro-8-(-pyrrolidinyl)-quinoline 、 3,4-二氯苯乙酸 在 碳酸氢钠 、 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 为溶剂， 生成 (+/-)decahydro-1-[(3,4-dichlorophenyl)acetyl]-8-(1-pyrrolidinyl) quinoline
  参考文献：
  名称：

  Decahydroquinolines and analgesic use thereof

  摘要：

  该专利描述了十氢喹啉的对映异构体和二对映异构体，化学式为##STR1##其中R.sub.1和R.sub.2分别选择自氢和1到5个碳原子的烷基，或与它们连接的氮原子一起形成一个5到6个成员的杂环，该杂环可以包括另一个杂原子，并且可以选择性地被取代；A从--(CH.sub.2).sub.n--和烷基取代的含有2到8个碳原子的烷基中选择，n是0到5的整数；Z从可选择性地取代的苯基，萘基，茚基，5到6个成员的单环杂环和双环杂环中选择，所有这些都未取代或被一个或多个取代基取代，以及其非毒性、药学上可接受的酸盐和季铵盐，具有中央镇痛作用。

  公开号：

  US04816465A1
• 作为产物：
  描述：

  8-pyrrolidinyl-5,6,7,8-tetrahydroquinoline 生成 (+/-)-decahydro-8-(-pyrrolidinyl)-quinoline
  参考文献：
  名称：

  CLEMENCE, FRANCOIS;FORTIN, MICHEL;LE, MARTRET ODILE

  摘要：

  DOI：

文献信息

• 8-amino decahydroquinolines having central nervous system analgesic
  申请人：Roussel Uclaf

  公开号：US04968700A1

  公开（公告）日：1990-11-06

  Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceuically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

  化合物的新对映异构体和顺反异构体，其化学式为##STR1##其中R.sub.1和R.sub.2分别选自氢和1到5个碳原子的烷基的群体，或与它们连接的氮原子共同形成一个5到6个成员的杂环，该杂环可包括另一个杂原子，并可选择性地被取代，A选自--(CH.sub.2).sub.n --和被烷基取代且具有2到8个碳原子的烷基，n为0到5的整数，Z选自可选择性取代的苯基、萘基、茚基、5到6个成员的单环杂环和双环杂环，所有这些均未被取代或被一个或多个取代基取代，以及它们的无毒、药学上可接受的酸盐和季铵盐，具有中枢镇痛作用。
• Novel hydroquinolines useful as intermediates
  申请人：Roussel Uclaf

  公开号：US04988810A1

  公开（公告）日：1991-01-29

  Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected from a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

  该专利描述了一种新的十氢喹啉的对映异构体和顺反异构体，其化学式为 ##STR1## 其中R.sub.1和R.sub.2分别选自氢和1至5个碳原子的烷基的群体，或者与它们连接的氮原子一起形成一个5至6个成员的杂环，该杂环可以包括另一个杂原子，并且可以选择性地被取代，A选自--(CH.sub.2).sub.n --和被烷基取代的烷基，其具有2至8个碳原子，n为0至5的整数，Z选自可选择性取代的苯基、萘基、茚基、5至6个成员的单环杂环和双环杂环，全部未取代或被一个或多个取代基取代，并具有中枢镇痛作用的非毒性、药学上可接受的酸盐和季铵盐。
• CLEMENCE, FRANCOIS;FORTIN, MICHEL;LE, MARTRET ODILE
  作者：CLEMENCE, FRANCOIS、FORTIN, MICHEL、LE, MARTRET ODILE

  DOI：——

  日期：——
• US5254566A
  申请人：——

  公开号：US5254566A

  公开（公告）日：1993-10-19
• Decahydroquinolines and analgesic use thereof
  申请人：Roussel Uclaf

  公开号：US04816465A1

  公开（公告）日：1989-03-28

  Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

  该专利描述了十氢喹啉的对映异构体和二对映异构体，化学式为##STR1##其中R.sub.1和R.sub.2分别选择自氢和1到5个碳原子的烷基，或与它们连接的氮原子一起形成一个5到6个成员的杂环，该杂环可以包括另一个杂原子，并且可以选择性地被取代；A从--(CH.sub.2).sub.n--和烷基取代的含有2到8个碳原子的烷基中选择，n是0到5的整数；Z从可选择性地取代的苯基，萘基，茚基，5到6个成员的单环杂环和双环杂环中选择，所有这些都未取代或被一个或多个取代基取代，以及其非毒性、药学上可接受的酸盐和季铵盐，具有中央镇痛作用。