| 1082740-00-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异恶唑并吡啶类
• CAS: 1082740-00-8
• 化学式: C₁₃H₉ClN₂O
• 分子量: 244.68
• InChiKey: CQLHDGCCDQMQGP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 (S)-(-)- α-甲基苄胺 在 tris(dibenzylideneacetone)dipalladium (0) 、 [1,3-bis(2,6-diisopropyl-phenyl)imidazol-2-ylidene](3-chloropyridyl)-palladium(II) dichloride 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 15.0h， 以5%的产率得到3-benzyl-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine
  参考文献：
  名称：

  Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

  摘要：

  A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More advanced analogues inhibit Plk1 with good enzymatic activity and modest cell-based activity. Differential selectivity among the three Plk isoforms is observed.

  DOI：

  10.1016/j.bmcl.2008.08.091
• 作为产物：
  描述：

  在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

  摘要：

  A series of 2-amino-isoxazolopyridines was designed and synthesized as Polo-like kinase (Plk) inhibitors. Key SAR and crystallographic data are discussed. More advanced analogues inhibit Plk1 with good enzymatic activity and modest cell-based activity. Differential selectivity among the three Plk isoforms is observed.

  DOI：

  10.1016/j.bmcl.2008.08.091