N-methylethanolamine phosphate | 6909-61-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: N-methylethanolamine phosphate
• 英文别名: 2-(methylamino)ethyl dihydrogen phosphate
• CAS: 6909-61-1
• 化学式: C₃H₁₀NO₄P
• 分子量: 155.09
• InChiKey: HZDCAHRLLXEQFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 氢气 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以84%的产率得到N-methylethanolamine phosphate
  参考文献：
  名称：

  Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3′ cleavage reaction

  摘要：

  The 3' end formation of mammalian pre-mRNA contributes to gene expression regulation by setting the downstream boundary of the 3' untranslated region, which in many genes carries regulatory sequences. A large number of protein cleavage factors participate in this pre-mRNA processing step, but chemical tools to manipulate this process are lacking. Guided by a hypothesis that a PPM1 family phosphatase negatively regulates the 3' cleavage reaction, we have found a variety of new small molecule activators of the in vitro reconstituted pre-mRNA 3' cleavage reaction. New activators include a cyclic peptide PPM1D inhibitor, a dipeptide with modifications common to histone tails, abscisic acid and an improved L-arginine beta-naphthylamide analog. The minimal concentration required for in vitro cleavage has been improved from 200 mu M to the 200 nM-100 mu M range. These compounds provide unexpected leads in the search for small molecule tools able to affect pre-mRNA 3' end formation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.12.006

文献信息

• Recherches sur la formation et la transformation des esters XIII. Sur la réaction des aminoalcools avec l'acide polyphosphorique:phosphorylation et/ou cyclisation
  作者：Emile Cherbuliez、J. Rabinowitz

  DOI：10.1002/hlca.19580410426

  日期：——

  In presence of pyro- or polyphosphoric acid at high temperature and low pressure, the aminoalkohols can undergo three types of reaction: (A) Phosphorylation, (B) Simultaneous phosphorylation and condensation, (C) Condensation.

  在高温和低压下存在焦磷酸或多磷酸的情况下，氨基醇会经历三种类型的反应：（A）磷酸化，（B）同时磷酸化和缩合，（C）缩合。
• Fuchs, Zeitschrift fur Biologie (Munich), 1939, vol. 99, p. 298,300
  作者：Fuchs

  DOI：——

  日期：——
• WOLF; NYC, Journal of Biological Chemistry, 1959, vol. 234, # 5, p. 1068 - 1071
  作者：WOLF、NYC

  DOI：——

  日期：——
• Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3′ cleavage reaction
  作者：Min Ting Liu、Nagaraja N. Nagre、Kevin Ryan

  DOI：10.1016/j.bmc.2013.12.006

  日期：2014.1

  The 3' end formation of mammalian pre-mRNA contributes to gene expression regulation by setting the downstream boundary of the 3' untranslated region, which in many genes carries regulatory sequences. A large number of protein cleavage factors participate in this pre-mRNA processing step, but chemical tools to manipulate this process are lacking. Guided by a hypothesis that a PPM1 family phosphatase negatively regulates the 3' cleavage reaction, we have found a variety of new small molecule activators of the in vitro reconstituted pre-mRNA 3' cleavage reaction. New activators include a cyclic peptide PPM1D inhibitor, a dipeptide with modifications common to histone tails, abscisic acid and an improved L-arginine beta-naphthylamide analog. The minimal concentration required for in vitro cleavage has been improved from 200 mu M to the 200 nM-100 mu M range. These compounds provide unexpected leads in the search for small molecule tools able to affect pre-mRNA 3' end formation. (C) 2013 Elsevier Ltd. All rights reserved.