Iminodihydrofuro[2,3-d]pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃[2,3-d]嘧啶
• 英文名称: Iminodihydrofuro[2,3-d]pyrimidine
• 英文别名: furo[2,3-d]pyrimidin-2-amine
• 化学式: C₆H₅N₃O
• 分子量: 135.12
• InChiKey: JPTYCVXLSHMYJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SUBSTITUTED 2, 4-DIAMINO-QUINOLINE DERIVATIVES FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES<br/>[FR] DÉRIVÉS SUBSTITUÉS DE 2, 4-DIAMINO-QUINOLÉINE POUR LEUR UTILISATION DANS LE TRAITEMENT DE MALADIES PROLIFÉRATIVES
  申请人：GENOSCIENCE PHARMA

  公开号：WO2017191599A1

  公开（公告）日：2017-11-09

  This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein which exhibit strong inhibition effects on various cancer cell lines. The compounds disclosed herein are useful for the treatment of proliferative diseases, including neoplastic diseases such as cancer and non- neoplastic disorders such as rheumatoid arthritis. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient and optionally one or more additional therapeutically active agents, including anticancer agents. This application also discloses methods for treating a proliferative disease, including neoplastic diseases such as cancer and non- neoplastic disorders such as rheumatoid arthritis.

  本申请披露了根据通用式（I）定义的化合物，其中所有变量如本文所述，这些化合物对各种癌细胞系表现出强烈的抑制作用。本文披露的化合物对于治疗增生性疾病非常有用，包括肿瘤性疾病如癌症和非肿瘤性疾病如类风湿性关节炎。还披露了含有通用式（I）化合物和至少一种载体、稀释剂或赋形剂以及可选的一种或多种其他治疗活性剂的药物组合物。本申请还披露了治疗增生性疾病的方法，包括肿瘤性疾病如癌症和非肿瘤性疾病如类风湿性关节炎的方法。
• Herbicidal sulfonamides
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0318620A1

  公开（公告）日：1989-06-07

  Compounds are of formula I: Wherein: E is CH2 or a single bond; W is O or S; R is H or CH3; Rx is H, F, Cl, CH3, OCH3, N(CH3)2 or OCHF2; R1 and R2 are selected from various organic groups, and A is selected from various heterocyclic groups, are useful as herbicides and plant growth regulators.

  化合物的化学式为I： 其中： E为CH2或单键； W为O或S； R为H或CH3； Rx为H，F，Cl，CH3，OCH3，N(CH3)2或OCHF2； R1和R2为不同的有机基团； A为不同的杂环基团； 这些化合物可用作除草剂和植物生长调节剂。
• HETEROCYCLIC COMPOUNDS AS JANUS KINASE INHIBITORS
  申请人：Babu Yarlagadda S.

  公开号：US20120309773A1

  公开（公告）日：2012-12-06

  The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for suppressing an immune response or treating cancer or a hematologic malignancy using compounds of formula I.

  本发明提供公式I的化合物：或其盐，如本文所述。本发明还提供包含公式I化合物的药物组合物，制备公式I化合物的方法，用于抑制免疫反应或治疗癌症或血液恶性肿瘤的治疗方法，使用公式I化合物的中间体有助于制备公式I化合物。
• Herbicidal pyrazolesulfonamides
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0176304A1

  公开（公告）日：1986-04-02

  Pyrazolesulfonamide derivatives of the formula wherein L is a pyrazole residue substituted by a 5- or 6-membered heterocyclic ring and optionally further substituted: W is O or S; R is H or CH3: and A is selected from mono- and bicyclic heterocyclic groups, especially pyrimidinyl and triazinyl; and their agriculturally suitable salts, exhibit herbicidal activity. Some also show a plant growth regulant effect. The novel compounds may be made by a variety of synthetic routes, e.g. by reacting an appropriate pyrazolesulfonamide with the corresponding methyl carbamic acid ester of formula CH30.CO.NRA.

  式中的吡唑磺酰胺衍生物 其中 L 是被 5 或 6 元杂环取代的吡唑残基，可选择进一步取代： W 是 O 或 S R 是 H 或 CH3 A 选自单环和双环杂环基团，特别是嘧啶基和三嗪基； 及其农业上适用的盐类具有除草活性。有些还具有植物生长调节作用。 这些新型化合物可以通过多种合成途径制得，例如，将适当的吡唑磺酰胺与相应的式 CH30.CO.NRA 的氨基甲酸甲酯反应。
• Herbicidal thiophenesulfonamides
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0207609A1

  公开（公告）日：1987-01-07

  Sulfonamide derivatives of formula or wherein R is H or CH3; R, and R1 are H, halogen, or various organic groups; Q and Q' are organic groups; W is 0 or S; A is a mono- or bicyclic heterocyclic group e.g. pyrimidinyl or triazinyl; X is CH3, OCH3, OCH2CH3, CH2OCH3 or OCF2H; Z is CH or N; and their agriculturally suitable salts, exhibit potent herbicidal activity. Some also show plant growth regulant activity. The novel compounds may be made by a variety of techniques, e.g. by reacting an appropriate thiophenesulfonyl isocyanate with an appropriate heterocyclic amine.

  式的磺酰胺衍生物 或 其中 R 为 H 或 CH3； R 和 R1 为 H、卤素或各种有机基团 Q 和 Q' 是有机基团 W 是 0 或 S； A 是单环或双环杂环基团，如嘧啶基或三嗪基； X 是 CH3、OCH3、OCH2CH3、CH2OCH3 或 OCF2H；Z 是 CH 或 N； 及其农业上适用的盐类具有很强的除草活性。有些还具有植物生长调节活性。 这些新型化合物可以通过多种技术制成，例如通过使适当的噻吩磺酰基异氰酸酯与适当的杂环胺反应。