Methyl 8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,9,13-pentaene-10-carboxylate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 鸡蛋花型生物碱
• 英文名称: Methyl 8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,9,13-pentaene-10-carboxylate
• 英文别名: methyl 8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,9,13-pentaene-10-carboxylate
• 化学式: C₁₉H₂₀N₂O₂
• 分子量: 308.4
• InChiKey: KQRZXSFABBICGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] ANIMAL MODELS, SCREENING METHODS, AND TREATMENT METHODS FOR INTRAOCULAR DISEASES OR DISORDERS<br/>[FR] MODÈLES D'ANIMAUX, PROCÉDÉS DE CRIBLAGE, ET PROCÉDÉS DE TRAITEMENT POUR MALADIES OU TROUBLES INTRAOCULAIRES
  申请人：ZHUHAI QIWEI BIO TECH LTD

  公开号：WO2020098630A1

  公开（公告）日：2020-05-22

  Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• [EN] METHOD OF TREATING AGE-RELATED MACULAR DEGENERATION<br/>[FR] MÉTHODES DE TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE
  申请人：ZHUHAI QIWEI BIO TECH LTD

  公开号：WO2020113759A1

  公开（公告）日：2020-06-11

  Provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Also provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.
• [EN] METHOD OF TREATING AGE-RELATED MACULAR DEGENERATION<br/>[FR] MÉTHODE DE TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE
  申请人：ZHUHAI QIWEI BIO TECH LTD

  公开号：WO2020113373A1

  公开（公告）日：2020-06-11

  Provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Also provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.