Imidazo<1,5-a>pyrazin-8(7H)-on | 56468-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并[1,5-a]吡嗪
• 英文名称: Imidazo<1,5-a>pyrazin-8(7H)-on
• 英文别名: 7H-imidazo[1,5-a]pyrazin-8-one；Imidazo[1,5-a]pyrazin-8(7H)-one；7H-imidazo[1,5-a]pyrazin-8-one
• CAS: 56468-21-4
• 化学式: C₆H₅N₃O
• mdl: MFCD19221408
• 分子量: 135.125
• InChiKey: SLYRIXNICMCXFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Imidazo<1,5-a>pyrazin-8(7H)-on 、 三氯氧磷 以47%的产率得到
  参考文献：
  名称：

  ABUSHANAB E.; LEE D.-Y.; GOODMANN L., J. ORG. CHEM. , 1975, 40, NO 23, 3376-3378

  摘要：

  DOI：
• 作为产物：
  描述：

  8-oxo-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid ethyl ester 以91%的产率得到
  参考文献：
  名称：

  ABUSHANAB E.; LEE D.-Y.; GOODMANN L., J. ORG. CHEM. , 1975, 40, NO 23, 3376-3378

  摘要：

  DOI：

文献信息

• [EN] PDE9I WITH IMIDAZO PYRAZINONE BACKBONE<br/>[FR] PDE9I AYANT UN SQUELETTE IMIDAZO PYRAZINONE
  申请人：LUNDBECK & CO AS H

  公开号：WO2013053690A1

  公开（公告）日：2013-04-18

  This invention is directed to compounds, which are PDE9 enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

  该发明涉及一类PDE9酶抑制剂化合物。该发明提供了一种药物组合物，包括该发明化合物的治疗有效量和药用载体。本发明还提供了制备式(I)化合物的方法。本发明还提供了一种治疗患有神经退行性疾病的受试者的方法，包括向受试者投与式(I)化合物的治疗有效量。本发明还提供了一种治疗患有精神疾病的受试者的方法，包括向受试者投与式(I)化合物的治疗有效量。
• ARYL AND HETEROARYL FUSED IMIDAZO[1,5-a]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10
  申请人：Malamas Michael S.

  公开号：US20090143367A1

  公开（公告）日：2009-06-04

  The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans.

  这项发明涉及咪唑并[1,5-a]吡嗪衍生物，涉及制备它们的方法，包括这些化合物的药物制剂以及将这些化合物作为磷酸二酯酶10（PDE10）的抑制剂作为活性成分，用于治疗哺乳动物，包括人类的中枢神经系统疾病的药物用途。
• [EN] IMIDAZOPYRAZINOL DERIVATIVES FOR THE TREATMENT OF CANCERS<br/>[FR] DÉRIVÉS D'IMIDAZOPYRAZINOL POUR LE TRAITEMENT DES CANCERS
  申请人：OSI PHARM INC

  公开号：WO2009091939A1

  公开（公告）日：2009-07-23

  Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-IR enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.

  化合物的结构式（I）及其药用盐，其中X1、X2、X3、X4、X5、X6、X7、R1和Q1在此处定义，抑制IGF-IR酶，可用于治疗和/或预防高增殖性疾病，如癌症、炎症、牛皮癣、过敏/哮喘、免疫系统疾病和疾病以及中枢神经系统疾病和病况。
• Aryl and heteroaryl fused imidazo [1,5-a] pyrazines as inhibitors of phosphodiesterase 10
  申请人：Hofgen Norbert

  公开号：US20090143391A1

  公开（公告）日：2009-06-04

  The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans.

  该发明涉及咪唑并[1,5-a]吡嗪衍生物，涉及制备它们的方法，包括这些化合物的药物制剂以及这些化合物的药用，这些化合物是磷酸二酯酶10（PDE10）的抑制剂，作为治疗哺乳动物中枢神经系统疾病的活性化合物，包括人类。
• [EN] PDE9 INHIBITORS WITH IMIDAZO TRIAZINONE BACKBONE AND IMIDAZO PYRAZINONE BACKBONE FOR TREATMENT OF PERIPHERAL DISEASES<br/>[FR] INHIBITEURS DE PDE9 PRÉSENTANT UN SQUELETTE D'IMIDAZO TRIAZINONE ET UN SQUELETTE D'IMIDAZO PYRAZINONE POUR LE TRAITEMENT DE MALADIES PÉRIPHÉRIQUES
  申请人：H LUNDBECK AS

  公开号：WO2017005786A1

  公开（公告）日：2017-01-12

  The present invention relates to PDE9 inhibitors and their use for treatment of benign prostate hyperplasia and sickle cell disease.

  本发明涉及PDE9抑制剂及其用于治疗良性前列腺增生和镰状细胞病的用途。