FAD | 73651-30-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 黄素核苷酸
• 英文名称: FAD
• 英文别名: Flavitan；[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [5-(7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate
• CAS: 73651-30-6
• 化学式: C₂₇H₃₃N₉O₁₅P₂
• 分子量: 785.558
• InChiKey: VWWQXMAJTJZDQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  53
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  356
• 氢给体数：
  9
• 氢受体数：
  20

文献信息

• Combined Pharmaceutical Preparation for Use in Treating Neuromuscular Disorders
  申请人：Universitäts-Kinderspital beider Basel

  公开号：EP2837390A1

  公开（公告）日：2015-02-18

  The present invention relates to a combined pharmaceutical preparation for use in a method for preventing or treating muscular dystrophy, comprising an activator of neuronal nitric oxide synthase, and a nitric oxide precursor, wherein said nitric oxide precursor is convertible by said nitric oxide synthase to nitric oxide

  本发明涉及一种用于预防或治疗肌肉萎缩症方法的组合药物制剂，包括神经元一氧化氮合酶激活剂和一氧化氮前体，其中所述一氧化氮前体可通过所述一氧化氮合酶转化为一氧化氮
• Composition for the management of nausea and vomiting
  申请人：DUCHESNAY INC.

  公开号：US10028941B2

  公开（公告）日：2018-07-24

  A pharmaceutical dosage system comprising (a) an effective amount of one or more of Doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof; (b) an effective amount of one or more of (i) Pyridoxine, (ii) an analog thereof, (iii) a derivative thereof, (iv) a prodrug thereof, (v) a metabolite thereof and (vi) a salt of any of (i)-(v); and (c) an effective amount of one or more compounds of formula (I) wherein R is H, PO3 or. The system exhibits an improved pharmacokinetic profile relative to the current Diclectin®/Diclegis® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting of pregnancy (NVP).

  一种药物剂型系统，包含(a)有效量的多西拉敏、其类似物、其衍生物、其原药、其代谢物和/或其盐中的一种或多种；(b) 有效量的(i)吡哆醇、(ii)其类似物、(iii)其衍生物、(iv)其原药、(v)其代谢物和(vi)(i)-(v)中任何一种的盐中的一种或多种；以及 (c) 有效量的式(I)化合物中的一种或多种，其中 R 是 H、PO3 或。与目前的 Diclectin®/Diclegis® 制剂相比，该体系具有更好的药代动力学特征，可用于缓解恶心和呕吐症状，例如妊娠恶心和呕吐（NVP）。
• Interference compensating two electrodes test strip
  申请人：Roche Diagnostics Operations, Inc.

  公开号：US10590458B2

  公开（公告）日：2020-03-17

  A method of detecting at least one analyte in a test sample is provided comprising a) contacting the test sample (i) to an active chemistry matrix changing at least one electrochemical property dependent on an enzymatic activity active in the presence of the analyte, the active chemistry matrix contacting a first electrode; and (ii) to an inactive chemistry matrix, the inactive chemistry matrix contacting a second electrode, b) closing an electrical circuit including the first electrode, the second electrode, and the active chemistry matrix and inactive chemistry matrix, followed by determining a first value of the at least one electrochemical property, c) inverting electrical polarity of the electrical circuit of b), followed by determining a second value of the at least one electrochemical property, and d) detecting the at least one analyte based on the first value and on the second value.

  本发明提供了一种检测测试样品中至少一种分析物的方法，包括 a) 将测试样品 (i) 与活性化学基质接触，改变至少一种依赖于分析物存在时活性酶活性的电化学性质，活性化学基质与第一电极接触；以及 (ii) 与非活性化学基质接触，非活性化学基质与第二电极接触；b) 闭合包括第一电极、第二电极、活性化学基质和非活性化学基质的电路；b) 闭合包括第一电极、第二电极、活性化学基质和非活性化学基质的电路，然后确定至少一种电化学性质的第一值， c) 反转 b) 电路的极性，然后确定至少一种电化学性质的第二值， d) 根据第一值和第二值检测至少一种分析物。
• COMPOSITION FOR THE MANAGEMENT OF NAUSEA AND VOMITING
  申请人：Duchesnay Inc.

  公开号：EP3024466B1

  公开（公告）日：2018-04-04
• INTERFERENCE COMPENSATING TWO ELECTRODES TEST STRIP
  申请人：Roche Diagnostics GmbH

  公开号：EP3186385A2

  公开（公告）日：2017-07-05