(1R)-1,13-dimethyl-10-(3-methylbut-2-enyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol | 359-83-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 6,7-苯并吗啡烷
• 英文名称: (1R)-1,13-dimethyl-10-(3-methylbut-2-enyl)-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
• CAS: 359-83-1；7313-83-9；7361-76-4；7488-49-5；21820-34-8；39188-58-4；55643-30-6；75257-91-9；146565-86-8
• 化学式: C₁₉H₂₇NO
• 分子量: 285.429
• InChiKey: VOKSWYLNZZRQPF-DNOPENIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compositions Comprising Enzyme-Cleavable Phenol-Modified Opioid Prodrugs and Inhibitors Thereof
  申请人：Jenkins Thomas E.

  公开号：US20110262360A1

  公开（公告）日：2011-10-27

  Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenol-modified opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the phenol-modified opioid prodrug so as to modify enzymatic cleavage of the phenol-modified opioid prodrug.

  提供了药物组合物及其使用方法，其中药物组合物包括一种苯酚修饰的阿片类前药，该前药提供酶控制释放苯酚类阿片类药物，并且包括与介导苯酚修饰的阿片类前药酶控制释放的酶相互作用的酶抑制剂，以调节苯酚修饰的阿片类前药的酶解。
• Pharmaceutical Compositions with Attenuated Release of Phenolic Opioids
  申请人：Jenkins Thomas E.

  公开号：US20110281886A1

  公开（公告）日：2011-11-17

  Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenolic opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug.

  本发明提供了一种药物组合物及其使用方法，其中药物组合物包括一种酚类阿片类前药，该前药提供酶控释酚类阿片类药物，以及一种酶抑制剂，该酶抑制剂与介导酚类阿片类前药酶控释酚类阿片类药物的酶相互作用，以减弱前药的酶解。
• OPIOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITIONS AND METHODS
  申请人：Evenstad Kenneth L.

  公开号：US20110275658A1

  公开（公告）日：2011-11-10

  The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts thereof) and a salt of a non-steroidal anti-inflammatory drug (NSAID).
• SUSTAINED RELEASE COMPOSITION COMPRISING AN AMINE AS ACTIVE AGENT AND A SALT OF A CYCLIC ORGANIC ACID
  申请人：Ortiz Ronnie

  公开号：US20130237559A1

  公开（公告）日：2013-09-12

  The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an amine-containing compound (e.g., an opioid) (including salts thereof) and a pharmaceutically acceptable salt of a non-NSAID cyclic organic acid compound.
• US8362029B2
  申请人：——

  公开号：US8362029B2

  公开（公告）日：2013-01-29