diallyl N,N-diisopropylphosphoramidite | 174968-03-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: diallyl N,N-diisopropylphosphoramidite
• 英文别名: diallyl diisopropylphosphoramidite；diallyl N,N-diisopropylphosphoramidate；N-bis(prop-2-enoxy)phosphoryl-N-propan-2-ylpropan-2-amine
• CAS: 174968-03-7
• 化学式: C₁₂H₂₄NO₃P
• 分子量: 261.301
• InChiKey: WGYOJAMQCTXVLP-UHFFFAOYSA-N

物化性质

• 沸点：
  291.7±43.0 °C(Predicted)
• 密度：
  0.998±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diallyl N,N-diisopropylphosphoramidite 、 (S)-1-(氯甲基)-5-羟基-1,2-二氢-3H-苯并[e]吲哚-3-羧酸叔丁酯 在 双氧水 作用下， 以 四氢呋喃 、 乙腈 、 水 为溶剂， 反应 2.75h， 以73%的产率得到tert-butyl (S)-5-(((bisallyloxy)phosphoryl)oxy)-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate
  参考文献：
  名称：

  [EN] ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS
  [FR] DIMÈRES D'ISOQUINOLIDINOBENZODIAZÉPINE (IQB)-1(CHLOROMÉTHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI)

  摘要：

  本文提供了异喹啉苯二氮卓啶（IQB）-1（氯甲基）-2,3-二氢-1H-苯并[e]吲哚（CBI）二聚体，包括它们的抗体药物结合物，以及用于杀灭细胞和治疗疾病的方法。

  公开号：

  WO2018071455A1

文献信息

• Sodium salt of disaccharide compound, production method and use of same
  申请人：Sakurai Shin

  公开号：US20080227991A1

  公开（公告）日：2008-09-18

  The present invention relates to a sodium salt represented by average formula (I): (wherein, m 1 , n 1 , m 2 and n 2 respectively and independently represent a positive number of 0 0r 2 or less, provided that m 1 +n 1 =2, m 2 +n 2 =2, 0

  本发明涉及一种由平均式(I)表示的钠盐：（其中，m1、n1、m2和n2分别独立地表示00r2或更小的正数，前提是m1+n1=2，m2+n2=2，0
• PROCESS FOR PRODUCTION OF LIPID A ANALOGUE
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP1939209A1

  公开（公告）日：2008-07-02

  Discloses is a process for producing α-D-glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]- or 1-(dihydrogen phosphate) tetrasodium salt which is useful as an active ingredient of a pharmaceutical or an intermediate for the synthesis thereof, which is environment-friendly and excellent in safety, operationality and reproducibility. A process for producing a compound represented by the formula (I) comprising the steps of reacting a compound represented by the formula (VIII) with a palladium catalyst in the presence of a nucleopholic agent and treating the product with a sodium source.

  本发明公开了一种制备α-D-葡萄糖吡喃糖，3-O-癸基-2-脱氧-6-O-[2-脱氧-3-O-[(3R)-3-甲氧基癸基]-6-O-甲基-2-[(11Z)-1-氧代-11-十八碳烯基]氨基]-4-O-膦酸-β-D-葡萄糖吡喃糖-2-[(1,3-二氧代-四十碳基)氨基]-或1-(二氢磷酸)四钠盐的方法，该方法可用作制药活性成分或其合成中间体，具有环保、安全、易操作和重复性优异的特点。一种制备式(I)化合物的方法，包括以下步骤：在核苷酸试剂的存在下，用钯催化剂反应式(VIII)化合物，并用钠源处理产物。
• SODIUM SALT OF DISACCHARIDE COMPOUND, METHOD FOR PRODUCING THE SAME, AND USE OF THE SAME
  申请人：Eisai R&D Management Co., Ltd.

  公开号：EP2096116A1

  公开（公告）日：2009-09-02

  Abstract: Disclosed are a sodium salt represented by the average formula (I) below, and a method for producing such a sodium salt. (In the formula, m1, n1 m2 and n2 independently represent 0 or a positive number not greater than 2, while satisfying m1 + n1 = 2, m2 + n2 = 2, 0 < m1 + m2 < 4 and 0 < n1 + n2 < 4) Also disclosed is a decomposition suppression method which makes a sodium salt represented by average formula (I) coexist with a sodium salt represented by the general formula (IV) below. This method enables improvement of long-term stability of a sodium salt represented by general formula (IV).

  摘要：本发明公开了一种由以下平均式(I)表示的钠盐，以及生产这种钠盐的方法。(式中，m1、n1 m2 和 n2 分别代表 0 或不大于 2 的正数，同时满足 m1 + n1 = 2，m2 + n2 = 2，0 < m1 + m2 < 4 和 0 < n1 + n2 < 4）还公开了一种分解抑制方法，该方法可使由平均式（I）表示的钠盐与由以下通式（IV）表示的钠盐共存。该方法可提高通式（IV）所代表的钠盐的长期稳定性。
• Method for producing polyether carbonate polyols
  申请人：Covestro Deutschland AG

  公开号：US10040901B2

  公开（公告）日：2018-08-07

  The invention relates to a method for producing polyether carbonate polyols by binding alkylene oxides and carbon dioxide to one or more H-functional starter substance/s in the presence of a double metal cyanide (DMC) catalyst, characterized in that (y) one or more H-functional starter substance/s and DMC catalyst are continuously metered into the reactor during the binding process, and the free alkylene oxide concentration in the reaction mixture amounts to 1.5 to 5.0 wt %, and the obtained reaction mixture is continuously discharged from the reactor.

  本发明涉及一种在双金属氰化物（DMC）催化剂存在下，通过将氧化亚烷和二氧化碳与一种或多种 H-官能起始物质结合而生产聚醚碳酸酯多元醇的方法，其特征在于：(y) 在结合过程中，将一种或多种 H-官能起始物质和 DMC 催化剂连续计量到反应器中，反应混合物中的游离氧化亚烷浓度为 1.5 至 5.0 wt %，得到的反应混合物连续从反应器中排出。
• Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
  作者：Junwon Choi、Lauren J. S. Wagner、Suzanne B. P. E. Timmermans、Stacy A. Malaker、Benjamin Schumann、Melissa A. Gray、Marjoke F. Debets、Megumi Takashima、Jase Gehring、Carolyn R. Bertozzi

  DOI：10.1021/jacs.9b04695

  日期：2019.8.28

  O-Linked alpha-N-acetylgalactosamine (O-GalNAc) glycans constitute a major part of the human glycome. They are difficult to study because of the complex interplay of 20 distinct glycosyltransferase isoenzymes that initiate this form of glycosylation, the polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts). Despite proven disease relevance, correlating the activity of individual GalNAc-Ts with biological function remains challenging due to a lack of tools to probe their substrate specificity in a complex biological environment. Here, we develop a "bump-hole" chemical reporter system for studying GalNAc-T activity in vitro. Individual GalNAc-Ts were rationally engineered to contain an enlarged active site (hole) and probed with a newly synthesized collection of 20 (bumped) uridine diphosphate N-acetylgalactosamine (UDP-GalNAc) analogs to identify enzyme-substrate pairs that retain peptide specificities but are otherwise completely orthogonal to native enzyme-substrate pairs. The approach was applicable to multiple GalNAc-T isoenzymes, including GalNAc-T1 and -T2 that prefer nonglycosylated peptide substrates and GalNAcT-10 that prefers a preglycosylated peptide substrate. A detailed investigation of enzyme kinetics and specificities revealed the robustness of the approach to faithfully report on GalNAc-T activity and paves the way for studying substrate specificities in living systems.