dihydroxyIPM | 168286-82-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: dihydroxyIPM
• 英文别名: N,N'-Bis(2-hydroxyethyl)phosphorodiamidic acid；bis(2-hydroxyethylamino)phosphinic acid
• CAS: 168286-82-6
• 化学式: C₄H₁₃N₂O₄P
• 分子量: 184.132
• InChiKey: OLWOOMNINOXPPC-UHFFFAOYSA-N

物化性质

• 沸点：
  406.3±55.0 °C(Predicted)
• 密度：
  1.428±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  102
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  葡磷酰胺 在 cacodylate buffer 作用下， 生成 帕利伐米 、 N-(2-chloroethyl)-N'-(aziridinyl) ifosfamide mustard 、 N-(2-Chloroethyl)-Na(2)-(2-hydroxyethyl)phosphorodiamidic acid 、 dihydroxyIPM
  参考文献：
  名称：

  Hydrolytic Pathway of Glufosfamide, a New Phosphorylated Anticancer Agent

  摘要：

  P-31 NMR was used to demonstrate that glufosfamide is hydrolyzed into isophosphoramide mustard (IPM) with a half-life of about 25 h at 37degreesC and pH 7.4 in buffer as well as in human plasma. Through a cascade of reactions, IPM gives rise to three final products, dihydroxyIPM, phosphate ion, and phosphorylethanolamine, which is by far the major compound.

  DOI：

  10.1080/10426500212229

文献信息

• Hydrolytic Pathway of Glufosfamide, a New Phosphorylated Anticancer Agent
  作者：Marie-Caroline Aoust de Rouvèze、Veronique Gilard、Robert Martino、Myriam Malet-Martino、Ulf Niemeyer

  DOI：10.1080/10426500212229

  日期：2002.6.1

  P-31 NMR was used to demonstrate that glufosfamide is hydrolyzed into isophosphoramide mustard (IPM) with a half-life of about 25 h at 37degreesC and pH 7.4 in buffer as well as in human plasma. Through a cascade of reactions, IPM gives rise to three final products, dihydroxyIPM, phosphate ion, and phosphorylethanolamine, which is by far the major compound.