代谢
四种毒素，分别是冈田酸（OA）、鳍藻毒素-1（DTX1）、扇贝毒素-6（PTX6）和亚苏毒素（YTX），它们都与腹泻性贝类中毒（DSP）有关，通过注射器给药给扇贝Patinopecten yessoensis，并使用液相色谱-质谱分析技术分析了它们在肝胰腺、闭壳肌和混合其他组织（外套膜、鳃、生殖腺）中的分布。无论注射部位是闭壳肌还是肝胰腺，毒素都专门残留在肝胰腺中。当注射到肝胰腺时，OA、DTX1和YTX分别被代谢为7-O-棕榈酰OA、7-O-棕榈酰DTX1和45-羟基亚苏毒素（45OH-YTX）。当毒素注射到闭壳肌时，这种代谢变化不明显。每种毒素在肝胰腺中的残留比例小于20%。用PTX6处理的扇贝死亡率低于用其他毒素处理的。
Four toxins, okadaic acid (OA), dinophysistoxin-1 (DTX1), pectenotoxin-6 (PTX6), and yessotoxin (YTX), all associated with diarrhetic shellfish poisoning (DSP), were administered via syringe to Scallops Patinopecten yessoensis and their distribution in the hepatopancreas, adductor muscle, and combined other tissues (mantle, gill, gonad) was analyzed by liquid chromatography-mass spectrometry. Toxins exclusively remained in the hepatopancreas irrespective of the injection site, adductor muscle or hepatopancreas. When injected into hepatopancreas, OA, DTX1, and YTX were metabolized to 7-O-palmitoylOA, 7-O-palmitoylDTX1 and 45-hydroxyyessotoxin (45OH-YTX), respectively. Such metabolic changes were insignificant when toxins were injected into the adductor muscle. The residual ratio for each toxin in the hepatopancreas was less than 20%. Mortalities of scallops treated with PTX6 were lower than those treated with other toxins.
来源:Hazardous Substances Data Bank (HSDB)