The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
本发明涉及用于诊断成像的对比剂,其具有延长血液保留时间的特性。具体而言,本发明涉及新颖化合物,其特征在于具有图像增强基团(
IEM);蛋白质血浆结合基团(PPBM);以及延长血液半衰期基团(BH
EM)。本发明还涉及包括这些化合物的药物组合物,以及使用这些化合物和组合物进行血液半衰期延长和诊断成像对比增强的方法。