O-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-β-D-galactopyranosyl-(1->3)-O-[6-deoxy-α-L-galactopyranosyl-(1->4)]-6-amino-1,5-anhydro-2,6-dideoxy-D-arabino-hexitol | 203794-60-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 糖脂
• 英文名称: O-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-β-D-galactopyranosyl-(1->3)-O-[6-deoxy-α-L-galactopyranosyl-(1->4)]-6-amino-1,5-anhydro-2,6-dideoxy-D-arabino-hexitol
• 英文别名: (2S)-2-[(2R,3R,4S,5S,6R)-2-[(2R,3S,4R)-2-(aminomethyl)-3-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3-cyclohexylpropanoic acid
• CAS: 203794-60-9
• 化学式: C₂₇H₄₇NO₁₄
• 分子量: 609.668
• InChiKey: PPAQTBGYOSKZKQ-WNJYOKQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  42
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  240
• 氢给体数：
  8
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  O-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-β-D-galactopyranosyl-(1->3)-O-[6-deoxy-α-L-galactopyranosyl-(1->4)]-6-amino-1,5-anhydro-2,6-dideoxy-D-arabino-hexitol 在 sodium hydroxide 、 pyridine-SO3 complex 作用下， 以 甲醇 为溶剂， 反应 56.0h， 以46%的产率得到O-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-β-D-galactopyranosyl-(1->3)-O-[6-deoxy-α-L-galactopyranosyl-(1->4)]-1,5-anhydro-2,6-dideoxy-6-(sulfoamino)-D-arabino-hexitol sodium salt
  参考文献：
  名称：

  Potent E-Selectin Antagonists

  摘要：

  In the search for drugs that could control excessive leukocyte extravasation, we now report on modifications of the already known potent E-selectin antagonist 3 containing a cyclohexyllactic acid residue and a glucal-derived building block. Thus, we describe the synthesis and biological evaluation of a series of derivatives 6 with modified glucal-derived moieties ((CH2NRR2)-R-1 instead of CH2OH in 3) to explore a hypothetical potential complementary interaction with E-selectin. However, similar activity profiles of most derivatives 6 and compound 3 do not support such an interaction, but rather indicate topological-structure changes of 6 (and 3) in the orientation of the neighboring fucose and galactose due to intramolecular steric interactions. The most potent E-selectin antagonist 6v showed >50-fold improved E-selectin inhibition compared to the weak selectin ligand sialyl Lewis(x) (sLe(x), 1; IC50 = 1000-1500 muM), but only a 2-fold improvement compared to 3. Compound 6x was tested in vivo in a murine model of acute inflammation and found to be as potent as 3 (ED50 = 15 mg/kg).

  DOI：

  10.1002/1522-2675(20001108)83:11<2893::aid-hlca2893>3.0.co;2-g
• 作为产物：
  描述：

  O-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-β-D-galactopyranosyl-(1->3)-O-[6-deoxy-2,3,4-tri-O-(phenylmethyl)-α-L-galactopyranosyl-(1->4)]-1,5-anhydro-6-azido-2,6-dideoxy-D-arabino-hexitol 在 palladium on activated charcoal 氢气 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 20.0h， 以67%的产率得到O-3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-β-D-galactopyranosyl-(1->3)-O-[6-deoxy-α-L-galactopyranosyl-(1->4)]-6-amino-1,5-anhydro-2,6-dideoxy-D-arabino-hexitol
  参考文献：
  名称：

  Potent E-Selectin Antagonists

  摘要：

  In the search for drugs that could control excessive leukocyte extravasation, we now report on modifications of the already known potent E-selectin antagonist 3 containing a cyclohexyllactic acid residue and a glucal-derived building block. Thus, we describe the synthesis and biological evaluation of a series of derivatives 6 with modified glucal-derived moieties ((CH2NRR2)-R-1 instead of CH2OH in 3) to explore a hypothetical potential complementary interaction with E-selectin. However, similar activity profiles of most derivatives 6 and compound 3 do not support such an interaction, but rather indicate topological-structure changes of 6 (and 3) in the orientation of the neighboring fucose and galactose due to intramolecular steric interactions. The most potent E-selectin antagonist 6v showed >50-fold improved E-selectin inhibition compared to the weak selectin ligand sialyl Lewis(x) (sLe(x), 1; IC50 = 1000-1500 muM), but only a 2-fold improvement compared to 3. Compound 6x was tested in vivo in a murine model of acute inflammation and found to be as potent as 3 (ED50 = 15 mg/kg).

  DOI：

  10.1002/1522-2675(20001108)83:11<2893::aid-hlca2893>3.0.co;2-g

文献信息

• [EN] GLYCOMIMETIC ANTAGONISTS FOR BOTH E- AND P-SELECTINS<br/>[FR] ANTAGONISTES GLYCOMIMETIQUES POUR LES SELECTINES DE TYPE E ET P
  申请人：GLYCOMIMETICS INC

  公开号：WO2005054264A3

  公开（公告）日：2007-03-22
• Nanomolar E-Selectin Inhibitors:  700-Fold Potentiation of Affinity by Multivalent Ligand Presentation
  作者：Gebhard Thoma、Rudolf O. Duthaler、John L. Magnani、John T. Patton

  DOI：10.1021/ja0164430

  日期：2001.10.1
• Potent E-Selectin Antagonists
  作者：Rolf Bänteli、Peter Herold、Christian Bruns、John T. Patton、John L. Magnani、Gebhard Thoma

  DOI：10.1002/1522-2675(20001108)83:11<2893::aid-hlca2893>3.0.co;2-g

  日期：2000.11.8

  In the search for drugs that could control excessive leukocyte extravasation, we now report on modifications of the already known potent E-selectin antagonist 3 containing a cyclohexyllactic acid residue and a glucal-derived building block. Thus, we describe the synthesis and biological evaluation of a series of derivatives 6 with modified glucal-derived moieties ((CH2NRR2)-R-1 instead of CH2OH in 3) to explore a hypothetical potential complementary interaction with E-selectin. However, similar activity profiles of most derivatives 6 and compound 3 do not support such an interaction, but rather indicate topological-structure changes of 6 (and 3) in the orientation of the neighboring fucose and galactose due to intramolecular steric interactions. The most potent E-selectin antagonist 6v showed >50-fold improved E-selectin inhibition compared to the weak selectin ligand sialyl Lewis(x) (sLe(x), 1; IC50 = 1000-1500 muM), but only a 2-fold improvement compared to 3. Compound 6x was tested in vivo in a murine model of acute inflammation and found to be as potent as 3 (ED50 = 15 mg/kg).