Lochnerinine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 冬青素型生物碱
• 英文名称: Lochnerinine
• 英文别名: methyl (1R,12S,20R)-12-ethyl-5-methoxy-14-oxa-8,17-diazahexacyclo[10.7.1.01,9.02,7.013,15.017,20]icosa-2(7),3,5,9-tetraene-10-carboxylate
• 化学式: C₂₂H₂₆N₂O₄
• 分子量: 382.5
• InChiKey: YKTXUUJZENEUGL-MKHRZCKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• MEANS AND METHODS TO ENHANCE THE PRODUCTION OF VINBLASTINE AND VINCRISTINE IN CATHARANTHUS ROSEUS
  申请人：VIB vzw

  公开号：EP1934355A2

  公开（公告）日：2008-06-25
• Means and Methods to Enhance the Production of Vinblastine and Vincristine in Catharanthus Roseus
  申请人：Goossens Alain

  公开号：US20090165167A1

  公开（公告）日：2009-06-25

  The present invention relates to the field of plant secondary metabolites, particularly terpenoid indole alkaloids. More particularly the present invention relates to the production of the anti-cancer metabolites vincristine and vinblastine. The invention provides novel polynucleotide sequences derived from Catharanthus roseus and the use of said polynucleotide sequences to stimulate the production of vinblastine and/or vincristine in plants of Catharanthus roseus and plant cell lines derived thereof. The invention further relates to recombinant plants, plant cells, tissue and organ cultures obtainable by the process of the invention.
• [EN] MEANS AND METHODS TO ENHANCE THE PRODUCTION OF VINBLASTINE AND VINCRISTINE IN CATHARANTHUS ROSEUS<br/>[FR] MOYENS ET PROCEDES PERMETTANT D'AMELIORER LA PRODUCTION DE VINBLASTINE ET DE VINCRISTINE DANS CATHARANTHUS ROSEUS
  申请人：VIB VZW

  公开号：WO2007031556A2

  公开（公告）日：2007-03-22

  [EN] The present invention relates to the field of plant secondary metabolites, particularly terpenoid indole alkaloids. More particularly the present invention relates to the production of the anti- cancer metabolites vincristine and vinblastine. The invention provides novel polynucleotide sequences derived from Catharanthus roseus and the use of said polynucleotide sequences to stimulate the production of vinblastine and/or vincristine in plants of Catharanthus roseus and plant cell lines derived thereof. The invention further relates to recombinant plants, plant cells, tissue and organ cultures obtainable by the process of the invention.
  [FR] L'invention concerne le domaine des métabolites secondaires végétaux, en particulier, des alcaloïdes d'indole-terpénoïde. L'invention concerne, plus particulièrement, la production de métabolites anticancéreux, tels que la vincristine et la vinblastine. L'invention concerne en outre des séquences polynucléotidiques dérivées de Catharanthus roseus et l'utilisation de ces séquences polynucléotidiques pour stimuler la production de vinblastine et/ou de vincristine chez les plantes de Catharanthus roseus et les lignées cellulaires végétales dérivées de celles-ci. L'invention concerne enfin des plantes de recombinaison, des cellules végétales et des cultures de tissus et d'organes pouvant être obtenus au moyen du procédé de l'invention.