N-propyl-N-isopropylphosphoramidic dichloride | 854542-36-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: N-propyl-N-isopropylphosphoramidic dichloride
• 英文别名: N-dichlorophosphoryl-N-propan-2-ylpropan-1-amine
• CAS: 854542-36-2
• 化学式: C₆H₁₄Cl₂NOP
• 分子量: 218.063
• InChiKey: QTXVALLPNWUZNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-异丙基丙胺 在 三氯氧磷 作用下， 以 苯 为溶剂， 生成 N-propyl-N-isopropylphosphoramidic dichloride
  参考文献：
  名称：

  使用碱性阴离子交换聚合物树脂/珠粒从二烷基胺和磷酰氯合成 N，N-二烷基磷酰胺二氯

  摘要：

  An efficient and operationally simple method is developed for the synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In the reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.

  DOI：

  10.1515/hc.2009.15.5.361

文献信息

• Synthesis Of N, N-Dialkyl Phosphoramidic Dichloride From Dialkyl Amine And Phosphoryl Chloride Using Basic Anion Exchange Polymer Resins/Beads
  作者：Brijesh K. Kushwaha、Hemendra K. Gupta、C. P. Shinde

  DOI：10.1515/hc.2009.15.5.361

  日期：2009.1

  An efficient and operationally simple method is developed for the synthesis of N, N-dialkyl phosphoramidic dichloride from dialkyl amine and phosphoryl chloride using basic anion exchange polymer resins/beads. In the reaction, polymer resin acts as a scavenger for HCl produced as by-product and desired product is distilled under vacuum. Reaction afforded N, N-dialkyl phosphoramidic dichloride in 3-4 hours with excellent yields from corresponding dialkylamine and phosphoryl chloride.