[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;formic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - （5'->5'）-二核苷酸
• 英文名称: [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate;formic acid
• 化学式: C22H30N7O19P3
• 分子量: 789.4
• InChiKey: LPHUJBNYWUHTOW-QYZPTAICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.83
• 重原子数：
  51
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  405
• 氢给体数：
  9
• 氢受体数：
  23

文献信息

• RECOMBINANT MICROORGANISMS COMPRISING NADPH DEPENDENT ENZYMES AND METHODS OF PRODUCTION THEREOF
  申请人：Lanzatech New Zealand Limited

  公开号：EP2951286A2

  公开（公告）日：2015-12-09
• [EN] RECOMBINANT MICROORGANISMS COMPRISING NADPH DEPENDENT ENZYMES AND METHODS OF PRODUCTION THEREOF<br/>[FR] MICRO-ORGANISMES RECOMBINÉS COMPRENANT DES ENZYMES NADPH-DÉPENDANTES ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：LANZATECH NEW ZEALAND LTD

  公开号：WO2014120852A2

  公开（公告）日：2014-08-07

  The invention provides a recombinant carboxydotrophic Clostridia microorganism with increased overall utilization of NADPH relative to a parent microorganism. Further, the invention provides a method of producing a recombinant carboxydotrophic Clostridia microorganism which exhibits increased NADPH utilization relative to a parental microorganism. In particular, the invention relates to increasing the overall utilization of NADPH in a recombinant carboxydotrophic Clostridia microorganism in order to increase the production of at least one fermentation product by the microorganism.