2,8-Diazaspiro[4.5]decane-2,3,8-tricarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 2,8-Diazaspiro[4.5]decane-2,3,8-tricarboxylic acid
• 英文别名: 2,8-diazaspiro[4.5]decane-2,3,8-tricarboxylic acid
• 化学式: C₁₁H₁₆N₂O₆
• 分子量: 272.25
• InChiKey: PKSFMBNBVNXGTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES<br/>[FR] RÉSOLUTION DE DÉRIVÉS DE DIAZASPIRO [4,5] DÉCANE OPTIQUEMENT ACTIFS
  申请人：ROIVANT SCIENCES GMBH

  公开号：WO2018087602A1

  公开（公告）日：2018-05-17

  The present invention is directed to diazaspiro[4.5]decane intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1). Processes of preparing the intermediates and their salts are also provided.

  本发明涉及一种用于制备螺环化合物的二氮杂螺[4.5]癸烷中间体及其盐，该化合物是色氨酸羟化酶（TPH）的抑制剂，特别是TPH1。本发明还提供了制备中间体及其盐的方法。
• RESOLUTION OF OPTICALLY ACTIVE DIAZASPIRO[4.5]DECANE DERIVATIVES
  申请人：Altavant Sciences GmbH

  公开号：EP3538530A1

  公开（公告）日：2019-09-18
• PROCESSES FOR PREPARING TPH1 INHIBITORS
  申请人：ALTAVANT SCIENCES GmbH

  公开号：US20190263815A1

  公开（公告）日：2019-08-29

  The present disclosure is directed to intermediates and salts thereof useful for the preparation of spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH 1). Processes of preparing the intermediates, salts, and TPH inhibitors are also provided.